The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China
ObjectiveIndependent and interactive effects of multiple metals levels in urine on the risk of hyperuricemia (HUA) in the elderly were investigated.MethodsA total of 6,508 individuals from the baseline population of the Shenzhen aging-related disorder cohort were included in this study. We detected...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1015202/full |
| _version_ | 1811165255024246784 |
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| author | Chao Huang Erwei Gao Feng Xiao Qiongzhen Wu Wei Liu Yi Luo Xiaohu Ren Xiao Chen Kaiwu He Haiyan Huang Qian Sun Desheng Wu Jianjun Liu |
| author_facet | Chao Huang Erwei Gao Feng Xiao Qiongzhen Wu Wei Liu Yi Luo Xiaohu Ren Xiao Chen Kaiwu He Haiyan Huang Qian Sun Desheng Wu Jianjun Liu |
| author_sort | Chao Huang |
| collection | DOAJ |
| description | ObjectiveIndependent and interactive effects of multiple metals levels in urine on the risk of hyperuricemia (HUA) in the elderly were investigated.MethodsA total of 6,508 individuals from the baseline population of the Shenzhen aging-related disorder cohort were included in this study. We detected urinary concentrations of 24 metals using inductively coupled plasma mass spectrometry, fitted unconditional logistic regression models, and the least absolute shrinkage and selection operator regression models for the selection of metals as well as unconditional stepwise logistic regression models and restricted cubic spline logistic regression models for assessing the associations of urinary metals and HUA risk, and finally applied generalized linear models to determine the interaction with urinary metals on the risk of HUA.ResultsUnconditional stepwise logistic regression models showed the association between urinary vanadium, iron, nickel, zinc, or arsenic and HUA risk (all P < 0.05). We revealed a negative linear dose–response relationship between urinary iron levels and HUA risk (Poverall < 0.001, Pnonliner = 0.682), a positive linear dose–response relationship between urinary zinc levels and HUA risk (Poverall < 0.001, Pnonliner = 0.513), and an additive interaction relationship between urinary low-iron and high-zinc levels and HUA risk (RERI = 0.31, 95% CI: 0.03–0.59; AP = 0.18, 95%CI: 0.02–0.34; S = 1.76, 95%CI: 1.69–3.49).ConclusionUrinary vanadium, iron, nickel, zinc, or arsenic levels were associated with HUA risk, and the additive interaction of low-iron (<78.56 μg/L) and high-zinc (≥385.39 μg/L) levels may lead to a higher risk of HUA. |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-10T15:34:19Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-3fa87201e1574a13ad7db44ce178be812023-02-13T08:02:48ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-02-011110.3389/fpubh.2023.10152021015202The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in ChinaChao Huang0Erwei Gao1Feng Xiao2Qiongzhen Wu3Wei Liu4Yi Luo5Xiaohu Ren6Xiao Chen7Kaiwu He8Haiyan Huang9Qian Sun10Desheng Wu11Jianjun Liu12Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaFood Inspection and Quarantine Technology Center of Shenzhen Customs, Shenzhen, Guangdong, ChinaFood Inspection and Quarantine Technology Center of Shenzhen Customs, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Luohu Hospital for Traditional Chinese Medicine, Shenzhen Luohu Hospital Group, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaShenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020–2024), Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaObjectiveIndependent and interactive effects of multiple metals levels in urine on the risk of hyperuricemia (HUA) in the elderly were investigated.MethodsA total of 6,508 individuals from the baseline population of the Shenzhen aging-related disorder cohort were included in this study. We detected urinary concentrations of 24 metals using inductively coupled plasma mass spectrometry, fitted unconditional logistic regression models, and the least absolute shrinkage and selection operator regression models for the selection of metals as well as unconditional stepwise logistic regression models and restricted cubic spline logistic regression models for assessing the associations of urinary metals and HUA risk, and finally applied generalized linear models to determine the interaction with urinary metals on the risk of HUA.ResultsUnconditional stepwise logistic regression models showed the association between urinary vanadium, iron, nickel, zinc, or arsenic and HUA risk (all P < 0.05). We revealed a negative linear dose–response relationship between urinary iron levels and HUA risk (Poverall < 0.001, Pnonliner = 0.682), a positive linear dose–response relationship between urinary zinc levels and HUA risk (Poverall < 0.001, Pnonliner = 0.513), and an additive interaction relationship between urinary low-iron and high-zinc levels and HUA risk (RERI = 0.31, 95% CI: 0.03–0.59; AP = 0.18, 95%CI: 0.02–0.34; S = 1.76, 95%CI: 1.69–3.49).ConclusionUrinary vanadium, iron, nickel, zinc, or arsenic levels were associated with HUA risk, and the additive interaction of low-iron (<78.56 μg/L) and high-zinc (≥385.39 μg/L) levels may lead to a higher risk of HUA.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1015202/fullurinary metal exposurehyperuricemiaserum uric acidinteractionsdose-response relationship |
| spellingShingle | Chao Huang Erwei Gao Feng Xiao Qiongzhen Wu Wei Liu Yi Luo Xiaohu Ren Xiao Chen Kaiwu He Haiyan Huang Qian Sun Desheng Wu Jianjun Liu The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China Frontiers in Public Health urinary metal exposure hyperuricemia serum uric acid interactions dose-response relationship |
| title | The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China |
| title_full | The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China |
| title_fullStr | The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China |
| title_full_unstemmed | The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China |
| title_short | The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China |
| title_sort | relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in china |
| topic | urinary metal exposure hyperuricemia serum uric acid interactions dose-response relationship |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1015202/full |
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