The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants
OBJECTIVE: Both soluble endothelial protein C receptor (sEPCR) and factor VIII (FVIII) seem to be potential mediators in thrombotic and inflammatory states. The aim of the present study was to determine the relation between plasma sEPCR and FVIII levels in a group of healthy Turkish infants. METHODS...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2011-03-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-36693 |
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| author | Filiz Şimşek Orhon Yonca Eğin Betül Ulukol Sevgi Başkan Nejat Akar |
| author_facet | Filiz Şimşek Orhon Yonca Eğin Betül Ulukol Sevgi Başkan Nejat Akar |
| author_sort | Filiz Şimşek Orhon |
| collection | DOAJ |
| description | OBJECTIVE: Both soluble endothelial protein C receptor (sEPCR) and factor VIII (FVIII) seem to be potential mediators in thrombotic and inflammatory states. The aim of the present study was to determine the relation between plasma sEPCR and FVIII levels in a group of healthy Turkish infants. METHODS: The study population consisted of 50 healthy infants aged 6 months (Group 1, n=23) and 12 months (Group 2, n=27) having no acute or chronic infection and/or disease. sEPCR levels and FVIII levels were measured by ELISA and one stage factor assay method, respectively. RESULTS: The sEPCR levels of the infants aged 6 months were found higher than those of the infants aged 12 months (p<0.001). There was a correlation between sEPCR and FVIII levels of the infants in Group 1 (6-month-old infants) (r=0.678, p<0.001). FVIII/sEPCR index was 0.73+-0.3 and 1.0+-0.5 in Group 1 and Group 2, respectively (p=0.027). A correlation between infant age and FVIII/sEPCR index was found (r=0.312, p=0.027). CONCLUSION: The FVIII/sEPCR index in healthy infants reflects the physiological condition of this population. The finding showing a positive relationship between sEPCR and FVIII levels suggests a possible interaction between these mediators in healthy infants aged six months. |
| first_indexed | 2024-04-10T14:09:44Z |
| format | Article |
| id | doaj.art-3fa9a7fc59194decaac678657d731f2e |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:09:44Z |
| publishDate | 2011-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-3fa9a7fc59194decaac678657d731f2e2023-02-15T16:09:48ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632011-03-01281273210.5152/tjh.2011.02TJH-36693The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infantsFiliz Şimşek Orhon0Yonca Eğin1Betül Ulukol2Sevgi Başkan3Nejat Akar4Department Of Pediatrics, Division Of Social Pediatrics, School Of Medicine, Ankara University, Ankara, TurkeyDepartment Of Pediatrics,division Of Pediatric Molecular Genetics, School Of Medicine, Ankara University, Ankara, TurkeyDepartment Of Pediatrics, Division Of Social Pediatrics, School Of Medicine, Ankara University, Ankara, TurkeyDepartment Of Pediatrics, Division Of Social Pediatrics, School Of Medicine, Ankara University, Ankara, TurkeyDepartment Of Pediatrics,division Of Pediatric Molecular Genetics, School Of Medicine, Ankara University, Ankara, TurkeyOBJECTIVE: Both soluble endothelial protein C receptor (sEPCR) and factor VIII (FVIII) seem to be potential mediators in thrombotic and inflammatory states. The aim of the present study was to determine the relation between plasma sEPCR and FVIII levels in a group of healthy Turkish infants. METHODS: The study population consisted of 50 healthy infants aged 6 months (Group 1, n=23) and 12 months (Group 2, n=27) having no acute or chronic infection and/or disease. sEPCR levels and FVIII levels were measured by ELISA and one stage factor assay method, respectively. RESULTS: The sEPCR levels of the infants aged 6 months were found higher than those of the infants aged 12 months (p<0.001). There was a correlation between sEPCR and FVIII levels of the infants in Group 1 (6-month-old infants) (r=0.678, p<0.001). FVIII/sEPCR index was 0.73+-0.3 and 1.0+-0.5 in Group 1 and Group 2, respectively (p=0.027). A correlation between infant age and FVIII/sEPCR index was found (r=0.312, p=0.027). CONCLUSION: The FVIII/sEPCR index in healthy infants reflects the physiological condition of this population. The finding showing a positive relationship between sEPCR and FVIII levels suggests a possible interaction between these mediators in healthy infants aged six months.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-36693soluble endothelial protein c receptor (sepcr)factor viiihealthy infantsthrombosis |
| spellingShingle | Filiz Şimşek Orhon Yonca Eğin Betül Ulukol Sevgi Başkan Nejat Akar The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants Turkish Journal of Hematology soluble endothelial protein c receptor (sepcr) factor viii healthy infants thrombosis |
| title | The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants |
| title_full | The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants |
| title_fullStr | The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants |
| title_full_unstemmed | The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants |
| title_short | The relation between soluble endothelial protein C receptor and factor VIII levels and FVIII/sEPCR index in healthy infants |
| title_sort | relation between soluble endothelial protein c receptor and factor viii levels and fviii sepcr index in healthy infants |
| topic | soluble endothelial protein c receptor (sepcr) factor viii healthy infants thrombosis |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-36693 |
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