From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immu...

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Bibliographic Details
Main Authors:	Loïs Coënon, Martin Villalba
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	CD16a NK cells ADCC monoclonal antibodies cell therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.913215/full

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