A miniature multi-contrast microscope for functional imaging in freely behaving animals
Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07926-z |
| _version_ | 1818342162333433856 |
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| author | Janaka Senarathna Hang Yu Callie Deng Alice L. Zou John B. Issa Darian H. Hadjiabadi Stacy Gil Qihong Wang Betty M. Tyler Nitish V. Thakor Arvind P. Pathak |
| author_facet | Janaka Senarathna Hang Yu Callie Deng Alice L. Zou John B. Issa Darian H. Hadjiabadi Stacy Gil Qihong Wang Betty M. Tyler Nitish V. Thakor Arvind P. Pathak |
| author_sort | Janaka Senarathna |
| collection | DOAJ |
| description | Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckle contrast. |
| first_indexed | 2024-12-13T16:10:18Z |
| format | Article |
| id | doaj.art-3faa9c8a2870428caac1dc902f7821bd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:10:18Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3faa9c8a2870428caac1dc902f7821bd2022-12-21T23:38:57ZengNature PortfolioNature Communications2041-17232019-01-0110111310.1038/s41467-018-07926-zA miniature multi-contrast microscope for functional imaging in freely behaving animalsJanaka Senarathna0Hang Yu1Callie Deng2Alice L. Zou3John B. Issa4Darian H. Hadjiabadi5Stacy Gil6Qihong Wang7Betty M. Tyler8Nitish V. Thakor9Arvind P. Pathak10Department of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineDepartment of Biomedical Engineering, Johns Hopkins University School of MedicineMeasuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckle contrast.https://doi.org/10.1038/s41467-018-07926-z |
| spellingShingle | Janaka Senarathna Hang Yu Callie Deng Alice L. Zou John B. Issa Darian H. Hadjiabadi Stacy Gil Qihong Wang Betty M. Tyler Nitish V. Thakor Arvind P. Pathak A miniature multi-contrast microscope for functional imaging in freely behaving animals Nature Communications |
| title | A miniature multi-contrast microscope for functional imaging in freely behaving animals |
| title_full | A miniature multi-contrast microscope for functional imaging in freely behaving animals |
| title_fullStr | A miniature multi-contrast microscope for functional imaging in freely behaving animals |
| title_full_unstemmed | A miniature multi-contrast microscope for functional imaging in freely behaving animals |
| title_short | A miniature multi-contrast microscope for functional imaging in freely behaving animals |
| title_sort | miniature multi contrast microscope for functional imaging in freely behaving animals |
| url | https://doi.org/10.1038/s41467-018-07926-z |
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