Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age
Introduction: Human T-lymphotropic virus (HTLV)-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women. This disease is characterized by a progressive loss of motor function and disruptions in sensory function in the lower limbs. HTLV-1 is...
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| Format: | Article |
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Oxford University Press
2018-12-01
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| Series: | Sexual Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2050116118300758 |
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| author | Adenilda Lima Lopes Martins, MD, PhD Maria Fernanda Rios Grassi, MD, PhD Alisson de Aquino Firmino, MSc Jean Paulo Lacerda Araujo, UGS Taiane Silva Paixao, UGS Bernardo Galvão-Castro, MD, PhD Ney Boa-Sorte, MD, PhD |
| author_facet | Adenilda Lima Lopes Martins, MD, PhD Maria Fernanda Rios Grassi, MD, PhD Alisson de Aquino Firmino, MSc Jean Paulo Lacerda Araujo, UGS Taiane Silva Paixao, UGS Bernardo Galvão-Castro, MD, PhD Ney Boa-Sorte, MD, PhD |
| author_sort | Adenilda Lima Lopes Martins, MD, PhD |
| collection | DOAJ |
| description | Introduction: Human T-lymphotropic virus (HTLV)-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women. This disease is characterized by a progressive loss of motor function and disruptions in sensory function in the lower limbs. HTLV-1 is also associated with isolated neurologic dysfunctions, overactive bladder, and erectile dysfunction. The occurrence of sexual dysfunction in HTLV-1–infected women remain unclear. Aim: To investigate associations between HTLV-1 infection and sexual dysfunction in both asymptomatic infected women and those diagnosed with HAM/TSP compared with uninfected women. Methods: HTLV-1–infected and uninfected women were assessed for sexual dysfunction using the Female Sexual Function Index instrument. Sexual dysfunction was considered if global Female Sexual Function Index scores were <26.5. Crude and adjusted prevalence ratios (PR) with 95% CI were calculated to identify associations between sexual dysfunction (outcome) and HTLV infection status–asymptomatic or HAM/TSP (main exposure), compared with uninfected women, and adjusted by sociodemographic and/or clinical characteristics (covariables). Results: HTLV-1–infected women (n = 72; 57 asymptomatic; 15 HAM/TSP) and HTLV-1 uninfected women (n = 49) were evaluated. The overall sexual dysfunction prevalence was 53.7% (65/121), which was higher in the HAM/TSP group (80.0%; adjusted PR 1.89; 95% CI 1.23–2.90) when compared with non-infected individuals (44.9%). Sexual dysfunction was found in 54.4% of the HTLV-1–infected asymptomatic women (PR 1.21; 95% CI 0.82–1.79). Sexual dysfunction was associated with income lower than 1 minimal wage (∼US $300, October 2017) and number of previous birthday. Conclusion: The obtained results indicate that sexual dysfunction is associated with HAM/TSP in women infected with HTLV-1 of reproductive age.Lima Lopes Martins A, Rios Grassi MF, de Aquino Firmino A, et al. Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. Sex Med 2018;6:324–331. Key Words: Sexual Dysfunction, Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis, Female Sexual Function Index, Human T-Lymphotropic Virus-1, Prevalence |
| first_indexed | 2024-03-12T06:29:48Z |
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| id | doaj.art-3fabc1f7b26742ec995770c7293d58d3 |
| institution | Directory Open Access Journal |
| issn | 2050-1161 |
| language | English |
| last_indexed | 2024-03-12T06:29:48Z |
| publishDate | 2018-12-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Sexual Medicine |
| spelling | doaj.art-3fabc1f7b26742ec995770c7293d58d32023-09-03T01:42:29ZengOxford University PressSexual Medicine2050-11612018-12-0164324331Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive AgeAdenilda Lima Lopes Martins, MD, PhD0Maria Fernanda Rios Grassi, MD, PhD1Alisson de Aquino Firmino, MSc2Jean Paulo Lacerda Araujo, UGS3Taiane Silva Paixao, UGS4Bernardo Galvão-Castro, MD, PhD5Ney Boa-Sorte, MD, PhD6Universidade Estadual de Feira de Santana, Feira de Santana, Brazil; Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil; Corresponding Author: Adenilda Lima Lopes Martins, MD, PhD, Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Av. D João VI, 275 Brotas Salvador - Bahia- Brasil. CEP:40290-000Centro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil; Laboratório Avançado de Saúde Pública, Instituto de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilCentro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, BrazilCentro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, BrazilCentro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, BrazilCentro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil; Laboratório Avançado de Saúde Pública, Instituto de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, BrazilCentro Integrativo e Interdisciplinar de Centro Integrativo e Interdisciplinar para Atendimento de Portadores do Vírus Linfotrópico de Células T Humanas (HTLV), Escola Bahiana de Medicina e Saúde Pública, Salvador, BrazilIntroduction: Human T-lymphotropic virus (HTLV)-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women. This disease is characterized by a progressive loss of motor function and disruptions in sensory function in the lower limbs. HTLV-1 is also associated with isolated neurologic dysfunctions, overactive bladder, and erectile dysfunction. The occurrence of sexual dysfunction in HTLV-1–infected women remain unclear. Aim: To investigate associations between HTLV-1 infection and sexual dysfunction in both asymptomatic infected women and those diagnosed with HAM/TSP compared with uninfected women. Methods: HTLV-1–infected and uninfected women were assessed for sexual dysfunction using the Female Sexual Function Index instrument. Sexual dysfunction was considered if global Female Sexual Function Index scores were <26.5. Crude and adjusted prevalence ratios (PR) with 95% CI were calculated to identify associations between sexual dysfunction (outcome) and HTLV infection status–asymptomatic or HAM/TSP (main exposure), compared with uninfected women, and adjusted by sociodemographic and/or clinical characteristics (covariables). Results: HTLV-1–infected women (n = 72; 57 asymptomatic; 15 HAM/TSP) and HTLV-1 uninfected women (n = 49) were evaluated. The overall sexual dysfunction prevalence was 53.7% (65/121), which was higher in the HAM/TSP group (80.0%; adjusted PR 1.89; 95% CI 1.23–2.90) when compared with non-infected individuals (44.9%). Sexual dysfunction was found in 54.4% of the HTLV-1–infected asymptomatic women (PR 1.21; 95% CI 0.82–1.79). Sexual dysfunction was associated with income lower than 1 minimal wage (∼US $300, October 2017) and number of previous birthday. Conclusion: The obtained results indicate that sexual dysfunction is associated with HAM/TSP in women infected with HTLV-1 of reproductive age.Lima Lopes Martins A, Rios Grassi MF, de Aquino Firmino A, et al. Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. Sex Med 2018;6:324–331. Key Words: Sexual Dysfunction, Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis, Female Sexual Function Index, Human T-Lymphotropic Virus-1, Prevalencehttp://www.sciencedirect.com/science/article/pii/S2050116118300758 |
| spellingShingle | Adenilda Lima Lopes Martins, MD, PhD Maria Fernanda Rios Grassi, MD, PhD Alisson de Aquino Firmino, MSc Jean Paulo Lacerda Araujo, UGS Taiane Silva Paixao, UGS Bernardo Galvão-Castro, MD, PhD Ney Boa-Sorte, MD, PhD Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age Sexual Medicine |
| title | Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age |
| title_full | Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age |
| title_fullStr | Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age |
| title_full_unstemmed | Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age |
| title_short | Human T-Lymphotropic Virus-1–Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age |
| title_sort | human t lymphotropic virus 1 associated myelopathy tropical spastic paraparesis is associated with sexual dysfunction in infected women of reproductive age |
| url | http://www.sciencedirect.com/science/article/pii/S2050116118300758 |
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