Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings
In this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA5MotB2). The structure suggested that the stator also rotates. The BFM is modeled as two rotating nano-rings that interact with each o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.866141/full |
| _version_ | 1818549916148957184 |
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| author | Yuansheng Cao Tairan Li Yuhai Tu |
| author_facet | Yuansheng Cao Tairan Li Yuhai Tu |
| author_sort | Yuansheng Cao |
| collection | DOAJ |
| description | In this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA5MotB2). The structure suggested that the stator also rotates. The BFM is modeled as two rotating nano-rings that interact with each other. Specifically, translocation of protons through the stator complex drives rotation of the MotA pentamer ring, which in turn drives rotation of the FliG ring in the rotor via interactions between the MotA ring of the stator and the FliG ring of the rotor. Preliminary results from the structure-informed model are consistent with the observed torque-speed relation. More importantly, the model predicts distinctive rotor and stator dynamics and their load dependence, which may be tested by future experiments. Possible approaches to verify and improve the model to further understand the molecular mechanism for torque generation in BFM are also discussed. |
| first_indexed | 2024-12-12T08:39:30Z |
| format | Article |
| id | doaj.art-3fabf174979d43c58309b090b6516a74 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T08:39:30Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3fabf174979d43c58309b090b6516a742022-12-22T00:30:49ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.866141866141Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-RingsYuansheng Cao0Tairan Li1Yuhai Tu2Department of Physics, University of California, San Diego, San Diego, CA, United StatesYuanpei College, Center for Quantitative Biology, Peking University, Beijing, ChinaIBM T. J. Watson Research Center, New York, NY, United StatesIn this article, we develop a mathematical model for the rotary bacterial flagellar motor (BFM) based on the recently discovered structure of the stator complex (MotA5MotB2). The structure suggested that the stator also rotates. The BFM is modeled as two rotating nano-rings that interact with each other. Specifically, translocation of protons through the stator complex drives rotation of the MotA pentamer ring, which in turn drives rotation of the FliG ring in the rotor via interactions between the MotA ring of the stator and the FliG ring of the rotor. Preliminary results from the structure-informed model are consistent with the observed torque-speed relation. More importantly, the model predicts distinctive rotor and stator dynamics and their load dependence, which may be tested by future experiments. Possible approaches to verify and improve the model to further understand the molecular mechanism for torque generation in BFM are also discussed.https://www.frontiersin.org/articles/10.3389/fmicb.2022.866141/fullbacterial flagellar motordynamicsstator structuremodelingproton motive forceproton translocation |
| spellingShingle | Yuansheng Cao Tairan Li Yuhai Tu Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings Frontiers in Microbiology bacterial flagellar motor dynamics stator structure modeling proton motive force proton translocation |
| title | Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings |
| title_full | Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings |
| title_fullStr | Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings |
| title_full_unstemmed | Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings |
| title_short | Modeling Bacterial Flagellar Motor With New Structure Information: Rotational Dynamics of Two Interacting Protein Nano-Rings |
| title_sort | modeling bacterial flagellar motor with new structure information rotational dynamics of two interacting protein nano rings |
| topic | bacterial flagellar motor dynamics stator structure modeling proton motive force proton translocation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.866141/full |
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