Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling

Comparative Analysis of Muscle Hypertrophy Models Reveals Divergent Gene Transcription Profiles and Points to Translational Regulation of Muscle Growth through Increased mTOR Signaling

Skeletal muscle mass is a result of the balance between protein breakdown and protein synthesis. It has been shown that multiple conditions of muscle atrophy are characterized by the common regulation of a specific set of genes, termed atrogenes. It is not known whether various models of muscle hype...

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Bibliographic Details
Main Authors: Marcelo G. Pereira, Kenneth A. Dyar, Leonardo Nogara, Francesca Solagna, Manuela Marabita, Martina Baraldo, Francesco Chemello, Elena Germinario, Vanina Romanello, Hendrik Nolte, Bert Blaauw
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
mTORC1
skeletal muscle
hypertrophy
ribosome biogenesis
immediate early genes
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Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00968/full

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