Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix
In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923001029 |
| _version_ | 1827876782529839104 |
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| author | Marco M. Bühler Hanna Honcharova-Biletska Chantal Pauli Dimitrios Chronas Kristina Bolten |
| author_facet | Marco M. Bühler Hanna Honcharova-Biletska Chantal Pauli Dimitrios Chronas Kristina Bolten |
| author_sort | Marco M. Bühler |
| collection | DOAJ |
| description | In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase inhibitors. Nonetheless, surgery remains the initial treatment of choice. We present the case of a 24-year-old patient suffering from a NTRK rearranged spindle cell neoplasm of the uterine cervix which was treated with a fertility preserving conservative surgical approach. |
| first_indexed | 2024-03-12T17:26:20Z |
| format | Article |
| id | doaj.art-3face2c61a404f9dacc4fa3b5e60d42a |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-12T17:26:20Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-3face2c61a404f9dacc4fa3b5e60d42a2023-08-05T05:16:13ZengElsevierGynecologic Oncology Reports2352-57892023-08-0148101233Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervixMarco M. Bühler0Hanna Honcharova-Biletska1Chantal Pauli2Dimitrios Chronas3Kristina Bolten4Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, SwitzerlandDepartment of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, SwitzerlandDepartment of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland; Medical Faculty, University of Zurich, Zurich, SwitzerlandGynecology and Gynecological Oncology, Department of Women’s Health, Zollikerberg Hospital, Zollikerberg, SwitzerlandGynecology and Gynecological Oncology, Department of Women’s Health, Zollikerberg Hospital, Zollikerberg, Switzerland; Corresponding author at: Gynecology and Gynecological Oncology, Department of Women’s Health, Zollikerberg Hospital, Zollikerberg, Switzerland.In depth molecular studies are constantly expanding our understanding and refining the classification of gynecological neoplasms. NTRK rearranged spindle cell neoplasms of the lower genital tract are an emerging entity, of particular interest due to possible targeted treatment with selective kinase inhibitors. Nonetheless, surgery remains the initial treatment of choice. We present the case of a 24-year-old patient suffering from a NTRK rearranged spindle cell neoplasm of the uterine cervix which was treated with a fertility preserving conservative surgical approach.http://www.sciencedirect.com/science/article/pii/S2352578923001029NTRK fusionCervical sarcomaNTRK rearranged tumorConservative surgery |
| spellingShingle | Marco M. Bühler Hanna Honcharova-Biletska Chantal Pauli Dimitrios Chronas Kristina Bolten Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix Gynecologic Oncology Reports NTRK fusion Cervical sarcoma NTRK rearranged tumor Conservative surgery |
| title | Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix |
| title_full | Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix |
| title_fullStr | Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix |
| title_full_unstemmed | Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix |
| title_short | Conservative surgical treatment with fertility preservation in a young adult with NTRK rearranged spindle cell neoplasm of the uterine cervix |
| title_sort | conservative surgical treatment with fertility preservation in a young adult with ntrk rearranged spindle cell neoplasm of the uterine cervix |
| topic | NTRK fusion Cervical sarcoma NTRK rearranged tumor Conservative surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923001029 |
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