Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/3/414 |
| _version_ | 1819140768655212544 |
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| author | Samir F. de A. Cavalcante Alessandro B. C. Simas Marcos C. Barcellos Victor G. M. de Oliveira Roberto B. Sousa Paulo A. de M. Cabral Kamil Kuča Tanos C. C. França |
| author_facet | Samir F. de A. Cavalcante Alessandro B. C. Simas Marcos C. Barcellos Victor G. M. de Oliveira Roberto B. Sousa Paulo A. de M. Cabral Kamil Kuča Tanos C. C. França |
| author_sort | Samir F. de A. Cavalcante |
| collection | DOAJ |
| description | This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons. |
| first_indexed | 2024-12-22T11:43:48Z |
| format | Article |
| id | doaj.art-3fad8319ca9440ee84e2b8cbdf4572ba |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-22T11:43:48Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3fad8319ca9440ee84e2b8cbdf4572ba2022-12-21T18:27:11ZengMDPI AGBiomolecules2218-273X2020-03-0110341410.3390/biom10030414biom10030414Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons ConventionSamir F. de A. Cavalcante0Alessandro B. C. Simas1Marcos C. Barcellos2Victor G. M. de Oliveira3Roberto B. Sousa4Paulo A. de M. Cabral5Kamil Kuča6Tanos C. C. França7Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, BrazilWalter Mors Institute of Research on Natural Products (IPPN), Federal University of Rio de Janeiro (UFRJ), CCS, Bloco H, Rio de Janeiro 21941-902, BrazilInstitute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, BrazilInstitute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, BrazilInstitute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, BrazilInstitute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, BrazilDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech RepublicDepartment of Chemistry, Faculty of Science, University of Hradec Králové, Rokitanskeho 62, 50003 Hradec Králové, Czech RepublicThis article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare method due to the action of nerve agents. The chemical concepts related to the irreversible inhibition of AChE, its reactivation, and aging are discussed, along with a relationship to the current international legislation on chemical weapons.https://www.mdpi.com/2218-273X/10/3/414acetylcholinesterasealzheimer’s diseasenerve agentschemical weapons convention |
| spellingShingle | Samir F. de A. Cavalcante Alessandro B. C. Simas Marcos C. Barcellos Victor G. M. de Oliveira Roberto B. Sousa Paulo A. de M. Cabral Kamil Kuča Tanos C. C. França Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention Biomolecules acetylcholinesterase alzheimer’s disease nerve agents chemical weapons convention |
| title | Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention |
| title_full | Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention |
| title_fullStr | Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention |
| title_full_unstemmed | Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention |
| title_short | Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention |
| title_sort | acetylcholinesterase the hub for neurodegenerative diseases and chemical weapons convention |
| topic | acetylcholinesterase alzheimer’s disease nerve agents chemical weapons convention |
| url | https://www.mdpi.com/2218-273X/10/3/414 |
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