Septins and Bacterial Infection
Septins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00127/full |
| _version_ | 1819267153397809152 |
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| author | Vincenzo Torraca Serge Mostowy |
| author_facet | Vincenzo Torraca Serge Mostowy |
| author_sort | Vincenzo Torraca |
| collection | DOAJ |
| description | Septins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work has shown that septins assemble in response to a wide variety of invasive bacterial pathogens, and septin assemblies can have different roles during the bacterial infection process. Here we review the interplay between septins and bacterial pathogens, highlighting septins as a structural determinant of host defense. We also discuss how investigation of septin assembly in response to bacterial infection can yield insight into basic cellular processes including phagocytosis, autophagy, and mitochondrial dynamics. |
| first_indexed | 2024-12-23T21:12:38Z |
| format | Article |
| id | doaj.art-3faddfcf95d74dcaac1cca0a5a8c364d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-23T21:12:38Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-3faddfcf95d74dcaac1cca0a5a8c364d2022-12-21T17:31:01ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-11-01410.3389/fcell.2016.00127228393Septins and Bacterial InfectionVincenzo Torraca0Serge Mostowy1Imperial College LondonImperial College LondonSeptins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work has shown that septins assemble in response to a wide variety of invasive bacterial pathogens, and septin assemblies can have different roles during the bacterial infection process. Here we review the interplay between septins and bacterial pathogens, highlighting septins as a structural determinant of host defense. We also discuss how investigation of septin assembly in response to bacterial infection can yield insight into basic cellular processes including phagocytosis, autophagy, and mitochondrial dynamics.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00127/fullAutophagyCytoskeletonListeriaMitochondriaSeptinsShigella |
| spellingShingle | Vincenzo Torraca Serge Mostowy Septins and Bacterial Infection Frontiers in Cell and Developmental Biology Autophagy Cytoskeleton Listeria Mitochondria Septins Shigella |
| title | Septins and Bacterial Infection |
| title_full | Septins and Bacterial Infection |
| title_fullStr | Septins and Bacterial Infection |
| title_full_unstemmed | Septins and Bacterial Infection |
| title_short | Septins and Bacterial Infection |
| title_sort | septins and bacterial infection |
| topic | Autophagy Cytoskeleton Listeria Mitochondria Septins Shigella |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00127/full |
| work_keys_str_mv | AT vincenzotorraca septinsandbacterialinfection AT sergemostowy septinsandbacterialinfection |