MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer

MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer

Background and aims: The purpose of the present study was to examine the pharmacodynamics features of MM-129 (1,2,4-triazine derivative) as a novel promising drug candidate against colon cancer. Methods: MM-129 was assessed for antitumor activity through an in vivo study on Cby.Cg-Foxn1nu/cmdb mice....

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Bibliographic Details
Main Authors:	Justyna Magdalena Hermanowicz, Krystyna Pawlak, Beata Sieklucka, Robert Czarnomysy, Iwona Kwiatkowska, Adam Kazberuk, Arkadiusz Surazynski, Mariusz Mojzych, Dariusz Pawlak
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Cancers
Subjects:	1,2,4-triazine derivative Akt—protein kinase B PD-L1—programmed death ligand 1 xenograft colon cancer
Online Access:	https://www.mdpi.com/2072-6694/13/13/3203

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