The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study
Background This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and...
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| Format: | Article |
| Language: | English |
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Yeungnam University College of Medicine, Yeungnam University Institute Medical Science
2023-01-01
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| Series: | Journal of Yeungnam Medical Science |
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| Online Access: | http://www.e-jyms.org/upload/pdf/jyms-2022-00213.pdf |
| _version_ | 1797867237514674176 |
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| author | Han Taek Jeong Joonkee Lee Hyeong Ho Jo Ho Gak Kim Jimin Han |
| author_facet | Han Taek Jeong Joonkee Lee Hyeong Ho Jo Ho Gak Kim Jimin Han |
| author_sort | Han Taek Jeong |
| collection | DOAJ |
| description | Background This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and December 2019 were included. Overall survival (OS) and progression-free survival (PFS) were analyzed. Results The median follow-up duration was 899 days. There were 109 patients in the AT group and 45 patients in the surveillance group. The patients in the AT group were younger (67 years vs. 74 years, p<0.001) and included more males (64.2% vs. 46.7%, p=0.044). The proportion of patients with stage III CCA was larger in the AT group than in the surveillance group (13.8% vs. 2.2%, p=0.005). In addition, AT did not improve OS (5-year OS rate, 69.3% in the AT group vs. 64.2% in the surveillance group, p=0.806) or PFS (5-year PFS rate, 42.6% in the AT group vs. 48.9% in the surveillance group, p=0.113). In multivariate analysis using the Cox proportional hazards model, stage III CCA (hazard ratio [HR], 10.81; 95% confidence interval [CI], 2.92–40.00; p<0.001) was a significant predictor of OS. American Society of Anesthesiologists classification II (HR, 0.50; 95% CI, 0.31–0.81; p=0.005), and American Joint Committee on Cancer stages II (HR, 3.14; 95% CI, 1.25–7.89; p=0.015) and III (HR, 8.08; 95% CI, 2.80–23.32; p<0.001) were independent predictors of PFS. Conclusion AT after R0 resection for CCA did not improve OS or PFS. |
| first_indexed | 2024-04-09T23:38:11Z |
| format | Article |
| id | doaj.art-3faf6b5267c044438f2d69b0142bc743 |
| institution | Directory Open Access Journal |
| issn | 2799-8010 |
| language | English |
| last_indexed | 2024-04-09T23:38:11Z |
| publishDate | 2023-01-01 |
| publisher | Yeungnam University College of Medicine, Yeungnam University Institute Medical Science |
| record_format | Article |
| series | Journal of Yeungnam Medical Science |
| spelling | doaj.art-3faf6b5267c044438f2d69b0142bc7432023-03-19T23:41:34ZengYeungnam University College of Medicine, Yeungnam University Institute Medical ScienceJournal of Yeungnam Medical Science2799-80102023-01-01401657710.12701/jyms.2022.002132720The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective studyHan Taek Jeong0Joonkee Lee1Hyeong Ho Jo2Ho Gak Kim3Jimin Han Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, KoreaBackground This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and December 2019 were included. Overall survival (OS) and progression-free survival (PFS) were analyzed. Results The median follow-up duration was 899 days. There were 109 patients in the AT group and 45 patients in the surveillance group. The patients in the AT group were younger (67 years vs. 74 years, p<0.001) and included more males (64.2% vs. 46.7%, p=0.044). The proportion of patients with stage III CCA was larger in the AT group than in the surveillance group (13.8% vs. 2.2%, p=0.005). In addition, AT did not improve OS (5-year OS rate, 69.3% in the AT group vs. 64.2% in the surveillance group, p=0.806) or PFS (5-year PFS rate, 42.6% in the AT group vs. 48.9% in the surveillance group, p=0.113). In multivariate analysis using the Cox proportional hazards model, stage III CCA (hazard ratio [HR], 10.81; 95% confidence interval [CI], 2.92–40.00; p<0.001) was a significant predictor of OS. American Society of Anesthesiologists classification II (HR, 0.50; 95% CI, 0.31–0.81; p=0.005), and American Joint Committee on Cancer stages II (HR, 3.14; 95% CI, 1.25–7.89; p=0.015) and III (HR, 8.08; 95% CI, 2.80–23.32; p<0.001) were independent predictors of PFS. Conclusion AT after R0 resection for CCA did not improve OS or PFS.http://www.e-jyms.org/upload/pdf/jyms-2022-00213.pdfadjuvant chemotherapybiliary tract surgical procedurescholangiocarcinomasurvival analysiswatchful waiting |
| spellingShingle | Han Taek Jeong Joonkee Lee Hyeong Ho Jo Ho Gak Kim Jimin Han The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study Journal of Yeungnam Medical Science adjuvant chemotherapy biliary tract surgical procedures cholangiocarcinoma survival analysis watchful waiting |
| title | The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study |
| title_full | The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study |
| title_fullStr | The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study |
| title_full_unstemmed | The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study |
| title_short | The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study |
| title_sort | effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after r0 resection a retrospective study |
| topic | adjuvant chemotherapy biliary tract surgical procedures cholangiocarcinoma survival analysis watchful waiting |
| url | http://www.e-jyms.org/upload/pdf/jyms-2022-00213.pdf |
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