Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis
Abstract Background Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren’s syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship betwee...
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BMC
2023-05-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-023-03062-2 |
| _version_ | 1827943305151774720 |
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| author | Meng Zhao Feiran Wei Han Li Zemin Wang Shuai Wang Yangyang Liu Gaoqiang Fei You Ge Pingmin Wei |
| author_facet | Meng Zhao Feiran Wei Han Li Zemin Wang Shuai Wang Yangyang Liu Gaoqiang Fei You Ge Pingmin Wei |
| author_sort | Meng Zhao |
| collection | DOAJ |
| description | Abstract Background Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren’s syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship between serum vitamin D levels and SS by using the Mendelian randomization (MR) approach. Methods In this study, genome-wide association studies (GWAS) summary statistics on serum vitamin D levels [sample size = 417,580 (UK Biobank)] and SS [sample size = 416,757 (cases = 2495, controls = 414,262) (FinnGen)] were used. The bi-directional MR analysis was then used to assess possible causal relationships. The major analysis method of MR was performed using inverse-variance weighted (IVW), supplemented by MR-Egger and the weighted median approaches. In addition, sensitivity analyses were used to ensure the stability of the results, including Cochran’s Q test, MR-PRESSO, MR-Egger intercept test, and the leave-one-out test. Results The MR suggested that no significant causal effects of serum 25(OH)D levels on SS risks were observed [odds ratio (OR) = 0.9824; 95% confidence interval (CI) = 0.7130 to 1.3538; P = 0.9137]. Similarly, no evidence supported the causal effects of SS on serum vitamin D levels (β: 0.0076, 95% CI: − 0.0031 to 0.0183; P = 0.1640). Conclusion This study found no obvious evidence that serum vitamin D level is causally associated with SS risks or vice versa. We call for larger sample size studies to further unravel the potential causal relationship and the exact mechanism. |
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| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-13T10:13:24Z |
| publishDate | 2023-05-01 |
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| series | Arthritis Research & Therapy |
| spelling | doaj.art-3fb335d6f1a741a3904e89cc2b9559e92023-05-21T11:22:34ZengBMCArthritis Research & Therapy1478-63622023-05-012511910.1186/s13075-023-03062-2Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysisMeng Zhao0Feiran Wei1Han Li2Zemin Wang3Shuai Wang4Yangyang Liu5Gaoqiang Fei6You Ge7Pingmin Wei8Department of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDivision of Rheumatology, Zhongda Hospital Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityAbstract Background Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren’s syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship between serum vitamin D levels and SS by using the Mendelian randomization (MR) approach. Methods In this study, genome-wide association studies (GWAS) summary statistics on serum vitamin D levels [sample size = 417,580 (UK Biobank)] and SS [sample size = 416,757 (cases = 2495, controls = 414,262) (FinnGen)] were used. The bi-directional MR analysis was then used to assess possible causal relationships. The major analysis method of MR was performed using inverse-variance weighted (IVW), supplemented by MR-Egger and the weighted median approaches. In addition, sensitivity analyses were used to ensure the stability of the results, including Cochran’s Q test, MR-PRESSO, MR-Egger intercept test, and the leave-one-out test. Results The MR suggested that no significant causal effects of serum 25(OH)D levels on SS risks were observed [odds ratio (OR) = 0.9824; 95% confidence interval (CI) = 0.7130 to 1.3538; P = 0.9137]. Similarly, no evidence supported the causal effects of SS on serum vitamin D levels (β: 0.0076, 95% CI: − 0.0031 to 0.0183; P = 0.1640). Conclusion This study found no obvious evidence that serum vitamin D level is causally associated with SS risks or vice versa. We call for larger sample size studies to further unravel the potential causal relationship and the exact mechanism.https://doi.org/10.1186/s13075-023-03062-2Mendelian randomizationVitamin D25(OH)DSjogren’s syndrome |
| spellingShingle | Meng Zhao Feiran Wei Han Li Zemin Wang Shuai Wang Yangyang Liu Gaoqiang Fei You Ge Pingmin Wei Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis Arthritis Research & Therapy Mendelian randomization Vitamin D 25(OH)D Sjogren’s syndrome |
| title | Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis |
| title_full | Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis |
| title_fullStr | Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis |
| title_full_unstemmed | Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis |
| title_short | Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis |
| title_sort | serum vitamin d levels and sjogren s syndrome bi directional mendelian randomization analysis |
| topic | Mendelian randomization Vitamin D 25(OH)D Sjogren’s syndrome |
| url | https://doi.org/10.1186/s13075-023-03062-2 |
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