Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-11-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2020.1830694 |
| _version_ | 1819121812295909376 |
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| author | Tyler Cannon Anshul Sinha Louis-Eric Trudeau Corinne F. Maurice Samantha Gruenheid |
| author_facet | Tyler Cannon Anshul Sinha Louis-Eric Trudeau Corinne F. Maurice Samantha Gruenheid |
| author_sort | Tyler Cannon |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1−/- mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1−/- PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1−/- and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1−/- mice and isobutyric acid increasing in wild-type mice. |
| first_indexed | 2024-12-22T06:42:30Z |
| format | Article |
| id | doaj.art-3fb4f6846e754f969654c6ca079484cf |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-22T06:42:30Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-3fb4f6846e754f969654c6ca079484cf2022-12-21T18:35:24ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-11-0112110.1080/19490976.2020.18306941830694Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s diseaseTyler Cannon0Anshul Sinha1Louis-Eric Trudeau2Corinne F. Maurice3Samantha Gruenheid4McGill UniversityMcGill UniversityUniversité de MontréalMcGill UniversityMcGill UniversityParkinson’s disease (PD) is a neurodegenerative disorder that has been shown to be influenced by the intestinal milieu. The gut microbiota is altered in PD patients, and murine studies have begun suggesting a causative role for the gut microbiota in progression of PD. We have previously shown that repeated infection with the intestinal murine pathogen Citrobacter rodentium resulted in the development of PD-like pathology in Pink1−/- mice compared to wild-type littermates. This addendum aims to expand this work by characterizing the gut microbiota during C. rodentium infection in our Pink1−/- PD model. We observed little disturbance to the fecal microbiota diversity both between infection timepoints and between Pink1−/- and wild-type control littermates. However, the level of short-chain fatty acids appeared to be altered over the course of infection with butyric acid significantly increasing in Pink1−/- mice and isobutyric acid increasing in wild-type mice.http://dx.doi.org/10.1080/19490976.2020.1830694gut microbiotaparkinson’s diseaseinfectiongut-brain axisautoimmunity |
| spellingShingle | Tyler Cannon Anshul Sinha Louis-Eric Trudeau Corinne F. Maurice Samantha Gruenheid Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease Gut Microbes gut microbiota parkinson’s disease infection gut-brain axis autoimmunity |
| title | Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease |
| title_full | Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease |
| title_fullStr | Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease |
| title_full_unstemmed | Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease |
| title_short | Characterization of the intestinal microbiota during Citrobacter rodentium infection in a mouse model of infection-triggered Parkinson’s disease |
| title_sort | characterization of the intestinal microbiota during citrobacter rodentium infection in a mouse model of infection triggered parkinson s disease |
| topic | gut microbiota parkinson’s disease infection gut-brain axis autoimmunity |
| url | http://dx.doi.org/10.1080/19490976.2020.1830694 |
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