Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine
Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway. Utilising specific monoclonal antibodies (HB-Tn1, HB-STn1 and HB-T1), we have investigated the expression of these simple mu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2009-12-01
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| Series: | European Journal of Histochemistry |
| Online Access: | http://ejh.pagepress.org/index.php/ejh/article/view/1600 |
| _version_ | 1811295097047744512 |
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| author | G Barresi G Tuccari G Giuffrè E Vitarelli M Grosso |
| author_facet | G Barresi G Tuccari G Giuffrè E Vitarelli M Grosso |
| author_sort | G Barresi |
| collection | DOAJ |
| description | Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway. Utilising specific monoclonal antibodies (HB-Tn1, HB-STn1 and HB-T1), we have investigated the expression of these simple mucin-type carbohydrate antigens in large intestine of 8 human foetuses at early gestational age (9-10 weeks), obtained after therapeutic abortion. In all cases the expression of Tn antigen was mainly localised as a thin rim at the cell membrane and occasionally in the supranuclear region of epithelial cells, while sialosyl-Tn antigen was documented in some goblet cell vacuoles and occasionally in the cytoplasm of columnar cells. T antigen was not expressed in any case. These results indicate that Tn and sialosyl-Tn antigens are expressed as early as nine weeks of gestation, further supporting the notion that they may be considered as oncodevelopmental cancerassociated antigens in the large intestine. |
| first_indexed | 2024-04-13T05:27:22Z |
| format | Article |
| id | doaj.art-3fb911d298e243979045f71361e9bb51 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-04-13T05:27:22Z |
| publishDate | 2009-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-3fb911d298e243979045f71361e9bb512022-12-22T03:00:32ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-12-014443596310.4081/1600Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestineG BarresiG TuccariG GiuffrèE VitarelliM GrossoTn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway. Utilising specific monoclonal antibodies (HB-Tn1, HB-STn1 and HB-T1), we have investigated the expression of these simple mucin-type carbohydrate antigens in large intestine of 8 human foetuses at early gestational age (9-10 weeks), obtained after therapeutic abortion. In all cases the expression of Tn antigen was mainly localised as a thin rim at the cell membrane and occasionally in the supranuclear region of epithelial cells, while sialosyl-Tn antigen was documented in some goblet cell vacuoles and occasionally in the cytoplasm of columnar cells. T antigen was not expressed in any case. These results indicate that Tn and sialosyl-Tn antigens are expressed as early as nine weeks of gestation, further supporting the notion that they may be considered as oncodevelopmental cancerassociated antigens in the large intestine.http://ejh.pagepress.org/index.php/ejh/article/view/1600 |
| spellingShingle | G Barresi G Tuccari G Giuffrè E Vitarelli M Grosso Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine European Journal of Histochemistry |
| title | Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine |
| title_full | Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine |
| title_fullStr | Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine |
| title_full_unstemmed | Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine |
| title_short | Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine |
| title_sort | expression of tn sialosyl tn and t antigens in human foetal large intestine |
| url | http://ejh.pagepress.org/index.php/ejh/article/view/1600 |
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