Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/3130 |
| _version_ | 1797510782219452416 |
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| author | Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim |
| author_facet | Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim |
| author_sort | Yvonne Xinyi Lim |
| collection | DOAJ |
| description | Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2. |
| first_indexed | 2024-03-10T05:36:09Z |
| format | Article |
| id | doaj.art-3fbd9eb42596497987797ce2776e1413 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:09Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3fbd9eb42596497987797ce2776e14132023-11-22T22:51:45ZengMDPI AGCells2073-44092021-11-011011313010.3390/cells10113130Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer TherapyYvonne Xinyi Lim0Hexian Lin1Sock Hong Seah2Yoon Pin Lim3Integrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, SingaporeIntegrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, SingaporeIntegrative Sciences and Engineering Programme, National University of Singapore, Singapore 119077, SingaporeDepartment of Biochemistry, National University of Singapore, Singapore 117596, SingaporeCancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated in a multitude of cancers. Elucidation of the Hippo pathway has revealed an increasing number of regulators that are implicated, some being potential therapeutic targets for cancer interventions. WW domain-binding protein 2 (WBP2) is an oncogenic transcriptional co-factor that interacts, amongst others, with two other transcriptional co-activators, YAP and TAZ, in the Hippo pathway. WBP2 was recently discovered to modulate the upstream Hippo signalling components by associating with LATS2 and WWC3. Exacerbating the complexity of the WBP2/Hippo network, WBP2 itself is reciprocally regulated by Hippo-mediated microRNA biogenesis, contributing to a positive feedback loop that further drives carcinogenesis. Here, we summarise the biological mechanisms of WBP2/Hippo reciprocal regulation and propose therapeutic strategies to overcome Hippo defects in cancers through targeting WBP2.https://www.mdpi.com/2073-4409/10/11/3130hippo pathwaycanceroncogenetherapeuticsreciprocal regulationWW-domain binding protein 2 |
| spellingShingle | Yvonne Xinyi Lim Hexian Lin Sock Hong Seah Yoon Pin Lim Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy Cells hippo pathway cancer oncogene therapeutics reciprocal regulation WW-domain binding protein 2 |
| title | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
| title_full | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
| title_fullStr | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
| title_full_unstemmed | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
| title_short | Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy |
| title_sort | reciprocal regulation of hippo and wbp2 signalling implications in cancer therapy |
| topic | hippo pathway cancer oncogene therapeutics reciprocal regulation WW-domain binding protein 2 |
| url | https://www.mdpi.com/2073-4409/10/11/3130 |
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