Conventional and biological therapies in atopic dermatitis – a literature review
Introduction: Atopic dermatitis is a chronic, relapsing disease with a multifactoral etiology. The basic disorder of the atopic dermatitis is the disruption of the epidermal barrier. The family history of atopy is a high risk factor of the development of the disease. The clinical manifestations are...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2023-08-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/45360 |
| _version_ | 1797692454926811136 |
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| author | Karolina Włodarczyk-Cybulska Natalia Sergiel Patrycja Maj Piotr Mozer Jakub Maternia Michał Lazar Agata Kania Aleksandra Serwik-Trandasir Malwina Gonet Karolina Miszczyk |
| author_facet | Karolina Włodarczyk-Cybulska Natalia Sergiel Patrycja Maj Piotr Mozer Jakub Maternia Michał Lazar Agata Kania Aleksandra Serwik-Trandasir Malwina Gonet Karolina Miszczyk |
| author_sort | Karolina Włodarczyk-Cybulska |
| collection | DOAJ |
| description |
Introduction: Atopic dermatitis is a chronic, relapsing disease with a multifactoral etiology. The basic disorder of the atopic dermatitis is the disruption of the epidermal barrier. The family history of atopy is a high risk factor of the development of the disease. The clinical manifestations are heterogeneous and vary depending on patient’s age, disease duration and current disease activity according to the SCORAD scale.
Objective: The aim of the review is to analyze the latest information on the characteristics, diagnosis and treatment of atopic dermatitis, including new biological medications.
Methods and materials: The sources available in PubMed database have been analyzed using the keywords: „atopic dermatitis”, „epidermal barrier”, „SCORAD index”, „topical treatment”, „biological therapy”, „Janus kinase inhibitors”.
Current state of knowledge: Atopic dermatitis is only treated symptomatically. The greatest therapeutic challenge is to reduce the pruritus which significantly impairs the quality of life. Topical corticosteroids may cause local side effects. The most severe cases of the disease require systemic treatment with immunosuppressants.
Conclusions: The complex pathogenesis of atopic dermatitis is the object of research. Understanding the immunological mechanisms responsible for the development of the disease allows to introduce new therapeutic options. Previous studies have confirmed the effectiveness of biological medications in reducing disease activity, which is a chance to improve the quality of live of the patients suffering from atopic dermatitis.
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| first_indexed | 2024-03-12T02:28:48Z |
| format | Article |
| id | doaj.art-3fbdb402d1974d6eb4589834663e08a8 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-03-12T02:28:48Z |
| publishDate | 2023-08-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-3fbdb402d1974d6eb4589834663e08a82023-09-05T10:49:04ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-08-0146110.12775/JEHS.2023.46.01.025Conventional and biological therapies in atopic dermatitis – a literature reviewKarolina Włodarczyk-Cybulska0Natalia Sergiel1Patrycja Maj2Piotr Mozer3Jakub Maternia4Michał Lazar5Agata Kania6Aleksandra Serwik-Trandasir7Malwina Gonet8Karolina Miszczyk9Uniwersytet Medyczny w Lublinie1st Military Clinical Hospital with the SPZOZ Polyclinic in Lublin, Lublin, Poland1st Military Clinical Hospital with the SPZOZ Polyclinic in Lublin, Lublin, Poland1st Military Clinical Hospital with the SPZOZ Polyclinic in Lublin, Lublin, PolandClinical Regional Hospital No. 2 of St. Jadwiga The Queen in Rzeszów, Rzeszów, PolandClinical Regional Hospital No. 2 of St. Jadwiga The Queen in Rzeszów, Rzeszów, PolandUniversity Clinical Centre of the Medical University of Warsaw, Warszawa, PolandUniversity Clinical Centre of the Medical University of Warsaw, Warszawa, Poland Poznan University of Medical Sciences, Faculty of Medicine, Poznań, PolandNowodworskie Medical Center in Nowy Dwór Mazowiecki, Nowy Dwór Mazowiecki, Poland Introduction: Atopic dermatitis is a chronic, relapsing disease with a multifactoral etiology. The basic disorder of the atopic dermatitis is the disruption of the epidermal barrier. The family history of atopy is a high risk factor of the development of the disease. The clinical manifestations are heterogeneous and vary depending on patient’s age, disease duration and current disease activity according to the SCORAD scale. Objective: The aim of the review is to analyze the latest information on the characteristics, diagnosis and treatment of atopic dermatitis, including new biological medications. Methods and materials: The sources available in PubMed database have been analyzed using the keywords: „atopic dermatitis”, „epidermal barrier”, „SCORAD index”, „topical treatment”, „biological therapy”, „Janus kinase inhibitors”. Current state of knowledge: Atopic dermatitis is only treated symptomatically. The greatest therapeutic challenge is to reduce the pruritus which significantly impairs the quality of life. Topical corticosteroids may cause local side effects. The most severe cases of the disease require systemic treatment with immunosuppressants. Conclusions: The complex pathogenesis of atopic dermatitis is the object of research. Understanding the immunological mechanisms responsible for the development of the disease allows to introduce new therapeutic options. Previous studies have confirmed the effectiveness of biological medications in reducing disease activity, which is a chance to improve the quality of live of the patients suffering from atopic dermatitis. https://apcz.umk.pl/JEHS/article/view/45360atopic dermatitisepidermal barrierSCORAD indextopical treatmentbiological therapyJanus kinase inhibitors |
| spellingShingle | Karolina Włodarczyk-Cybulska Natalia Sergiel Patrycja Maj Piotr Mozer Jakub Maternia Michał Lazar Agata Kania Aleksandra Serwik-Trandasir Malwina Gonet Karolina Miszczyk Conventional and biological therapies in atopic dermatitis – a literature review Journal of Education, Health and Sport atopic dermatitis epidermal barrier SCORAD index topical treatment biological therapy Janus kinase inhibitors |
| title | Conventional and biological therapies in atopic dermatitis – a literature review |
| title_full | Conventional and biological therapies in atopic dermatitis – a literature review |
| title_fullStr | Conventional and biological therapies in atopic dermatitis – a literature review |
| title_full_unstemmed | Conventional and biological therapies in atopic dermatitis – a literature review |
| title_short | Conventional and biological therapies in atopic dermatitis – a literature review |
| title_sort | conventional and biological therapies in atopic dermatitis a literature review |
| topic | atopic dermatitis epidermal barrier SCORAD index topical treatment biological therapy Janus kinase inhibitors |
| url | https://apcz.umk.pl/JEHS/article/view/45360 |
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