Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018
Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infection...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2023-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/2/22-0950_article |
| _version_ | 1828056094674518016 |
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| author | Ian D. Plumb Allison C. Brown Erin K. Stokes Jessica C. Chen Heather Carleton Beth Tolar Preethi Sundararaman Amy Saupe Daniel C. Payne Hazel J. Shah Jason P. Folster Cindy R. Friedman |
| author_facet | Ian D. Plumb Allison C. Brown Erin K. Stokes Jessica C. Chen Heather Carleton Beth Tolar Preethi Sundararaman Amy Saupe Daniel C. Payne Hazel J. Shah Jason P. Folster Cindy R. Friedman |
| author_sort | Ian D. Plumb |
| collection | DOAJ |
| description |
Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% of Salmonella infections during 2009–2013 to 2.6% during 2014–2018; the proportion of Salmonella 4,[5],12:i:- isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015–2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine would likely avert human infections.
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| first_indexed | 2024-04-10T20:48:56Z |
| format | Article |
| id | doaj.art-3fbdbc401a2f44aa86fdf9a336b83e18 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-10T20:48:56Z |
| publishDate | 2023-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-3fbdbc401a2f44aa86fdf9a336b83e182023-01-23T18:21:51ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-02-0129231432210.3201/eid2902.220950Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018Ian D. PlumbAllison C. BrownErin K. StokesJessica C. ChenHeather CarletonBeth TolarPreethi SundararamanAmy SaupeDaniel C. PayneHazel J. ShahJason P. FolsterCindy R. Friedman Reports of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% of Salmonella infections during 2009–2013 to 2.6% during 2014–2018; the proportion of Salmonella 4,[5],12:i:- isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015–2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine would likely avert human infections. https://wwwnc.cdc.gov/eid/article/29/2/22-0950_articleSalmonellabacteriaantimicrobial resistancefood safetySalmonella 4,[5],12:i:-Salmonella Typhimurium |
| spellingShingle | Ian D. Plumb Allison C. Brown Erin K. Stokes Jessica C. Chen Heather Carleton Beth Tolar Preethi Sundararaman Amy Saupe Daniel C. Payne Hazel J. Shah Jason P. Folster Cindy R. Friedman Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 Emerging Infectious Diseases Salmonella bacteria antimicrobial resistance food safety Salmonella 4,[5],12:i:- Salmonella Typhimurium |
| title | Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 |
| title_full | Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 |
| title_fullStr | Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 |
| title_full_unstemmed | Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 |
| title_short | Increased Multidrug-Resistant Salmonella enterica I Serotype 4,[5],12:i:- Infections Associated with Pork, United States, 2009–2018 |
| title_sort | increased multidrug resistant salmonella enterica i serotype 4 5 12 i infections associated with pork united states 2009 2018 |
| topic | Salmonella bacteria antimicrobial resistance food safety Salmonella 4,[5],12:i:- Salmonella Typhimurium |
| url | https://wwwnc.cdc.gov/eid/article/29/2/22-0950_article |
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