Strategies to induce broadly protective antibody responses to viral glycoproteins
Introduction: Currently, several universal/broadly protective influenza virus vaccine candidates are under development. Many of these vaccines are based on strategies to induce protective antibody responses against the surface glycoproteins of antigenically and genetically diverse influenza viruses....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1299576 |
| _version_ | 1797680409795887104 |
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| author | F Krammer |
| author_facet | F Krammer |
| author_sort | F Krammer |
| collection | DOAJ |
| description | Introduction: Currently, several universal/broadly protective influenza virus vaccine candidates are under development. Many of these vaccines are based on strategies to induce protective antibody responses against the surface glycoproteins of antigenically and genetically diverse influenza viruses. These strategies might also be applicable to surface glycoproteins of a broad range of other important viral pathogens. Areas covered: Common strategies include sequential vaccination with divergent antigens, multivalent approaches, vaccination with glycan-modified antigens, vaccination with minimal antigens and vaccination with antigens that have centralized/optimized sequences. Here we review these strategies and the underlying concepts. Furthermore, challenges, feasibility and applicability to other viral pathogens are discussed. Expert commentary: Several broadly protective/universal influenza virus vaccine strategies will be tested in humans in the coming years. If successful in terms of safety and immunological readouts, they will move forward into efficacy trials. In the meantime, successful vaccine strategies might also be applied to other antigenically diverse viruses of concern. |
| first_indexed | 2024-03-11T23:29:36Z |
| format | Article |
| id | doaj.art-3fc40958092b4b3d85de05b55ac1d623 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:36Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-3fc40958092b4b3d85de05b55ac1d6232023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-05-0116550351310.1080/14760584.2017.12995761299576Strategies to induce broadly protective antibody responses to viral glycoproteinsF Krammer0Icahn School of Medicine at Mount SinaiIntroduction: Currently, several universal/broadly protective influenza virus vaccine candidates are under development. Many of these vaccines are based on strategies to induce protective antibody responses against the surface glycoproteins of antigenically and genetically diverse influenza viruses. These strategies might also be applicable to surface glycoproteins of a broad range of other important viral pathogens. Areas covered: Common strategies include sequential vaccination with divergent antigens, multivalent approaches, vaccination with glycan-modified antigens, vaccination with minimal antigens and vaccination with antigens that have centralized/optimized sequences. Here we review these strategies and the underlying concepts. Furthermore, challenges, feasibility and applicability to other viral pathogens are discussed. Expert commentary: Several broadly protective/universal influenza virus vaccine strategies will be tested in humans in the coming years. If successful in terms of safety and immunological readouts, they will move forward into efficacy trials. In the meantime, successful vaccine strategies might also be applied to other antigenically diverse viruses of concern.http://dx.doi.org/10.1080/14760584.2017.1299576influenzauniversal vaccineviral glycoproteinsfilovirusarenavirushcvhivconserved epitopeheterosubtypic immunityhemagglutinin |
| spellingShingle | F Krammer Strategies to induce broadly protective antibody responses to viral glycoproteins Expert Review of Vaccines influenza universal vaccine viral glycoproteins filovirus arenavirus hcv hiv conserved epitope heterosubtypic immunity hemagglutinin |
| title | Strategies to induce broadly protective antibody responses to viral glycoproteins |
| title_full | Strategies to induce broadly protective antibody responses to viral glycoproteins |
| title_fullStr | Strategies to induce broadly protective antibody responses to viral glycoproteins |
| title_full_unstemmed | Strategies to induce broadly protective antibody responses to viral glycoproteins |
| title_short | Strategies to induce broadly protective antibody responses to viral glycoproteins |
| title_sort | strategies to induce broadly protective antibody responses to viral glycoproteins |
| topic | influenza universal vaccine viral glycoproteins filovirus arenavirus hcv hiv conserved epitope heterosubtypic immunity hemagglutinin |
| url | http://dx.doi.org/10.1080/14760584.2017.1299576 |
| work_keys_str_mv | AT fkrammer strategiestoinducebroadlyprotectiveantibodyresponsestoviralglycoproteins |