The metabolic outcomes of growth hormone treatment in children are gender specific
Objective: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal growth hormone deficiency (GHD) children at diagnosis and during GH treatment (GHT). Design: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopath...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2018-07-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/7/7/879.full |
| _version_ | 1819118053595545600 |
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| author | Alessandro Ciresi Stefano Radellini Valentina Guarnotta Maria Grazia Mineo Carla Giordano |
| author_facet | Alessandro Ciresi Stefano Radellini Valentina Guarnotta Maria Grazia Mineo Carla Giordano |
| author_sort | Alessandro Ciresi |
| collection | DOAJ |
| description | Objective: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal growth hormone deficiency (GHD) children at diagnosis and during GH treatment (GHT).
Design: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopathic GHD were retrospectively evaluated.
Methods: Body height, BMI, waist circumference (WC), IGF-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin levels, insulin sensitivity and secretion indices were evaluated at baseline and after 24 months of GHT.
Results: At baseline, no significant difference was found in all clinical, hormonal and metabolic parameters between males and females. After 24 months of GHT, both males and females showed a significant increase in height (both P < 0.001), BMI (both P < 0.001), WC (P < 0.001 and P = 0.004, respectively), IGF-I (both P < 0.001), fasting glucose (P < 0.001 and P = 0.001, respectively), fasting insulin (both P < 0.001) and Homa-IR (both P < 0.001), with a concomitant significant decrease in insulin sensitivity index (ISI) (both P < 0.001) and oral disposition index (DIo) (P = 0.001 and P < 0.001, respectively). At 24 months of GHT, females showed significantly higher BMI (P = 0.027), lower ISI (P < 0.001) and DIo (P < 0.001), in concomitance with a significant greater change from baseline to 24 months of BMI (P = 0.013), WC (P < 0.001), ISI (P = 0.002) and DIo (P = 0.072), although the latter does not reach statistical significance.
Conclusions: Twenty-four months of GHT in prepubertal children leads to different metabolic outcomes according to gender, with a greater reduction in insulin sensitivity in females, regardless of auxological and hormonal parameters. Therefore, prepubertal GHD females should probably need a more proper monitoring in clinical practice. |
| first_indexed | 2024-12-22T05:42:46Z |
| format | Article |
| id | doaj.art-3fc449c3b5804561bfde88b8d6fb44e5 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-22T05:42:46Z |
| publishDate | 2018-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-3fc449c3b5804561bfde88b8d6fb44e52022-12-21T18:37:09ZengBioscientificaEndocrine Connections2049-36142049-36142018-07-0177879887https://doi.org/10.1530/EC-18-0135The metabolic outcomes of growth hormone treatment in children are gender specificAlessandro Ciresi0Stefano Radellini1Valentina Guarnotta2Maria Grazia Mineo3Carla Giordano4Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, ItalySection of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, ItalySection of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, ItalySection of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, ItalySection of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, ItalyObjective: To evaluate the impact of gender on the clinical and metabolic parameters in prepubertal growth hormone deficiency (GHD) children at diagnosis and during GH treatment (GHT). Design: The data of 105 prepubertal children (61 males, 44 females, mean age 6.8 ± 0.7 years) affected by idiopathic GHD were retrospectively evaluated. Methods: Body height, BMI, waist circumference (WC), IGF-I, HbA1c, lipid profile, fasting and after-OGTT glucose and insulin levels, insulin sensitivity and secretion indices were evaluated at baseline and after 24 months of GHT. Results: At baseline, no significant difference was found in all clinical, hormonal and metabolic parameters between males and females. After 24 months of GHT, both males and females showed a significant increase in height (both P < 0.001), BMI (both P < 0.001), WC (P < 0.001 and P = 0.004, respectively), IGF-I (both P < 0.001), fasting glucose (P < 0.001 and P = 0.001, respectively), fasting insulin (both P < 0.001) and Homa-IR (both P < 0.001), with a concomitant significant decrease in insulin sensitivity index (ISI) (both P < 0.001) and oral disposition index (DIo) (P = 0.001 and P < 0.001, respectively). At 24 months of GHT, females showed significantly higher BMI (P = 0.027), lower ISI (P < 0.001) and DIo (P < 0.001), in concomitance with a significant greater change from baseline to 24 months of BMI (P = 0.013), WC (P < 0.001), ISI (P = 0.002) and DIo (P = 0.072), although the latter does not reach statistical significance. Conclusions: Twenty-four months of GHT in prepubertal children leads to different metabolic outcomes according to gender, with a greater reduction in insulin sensitivity in females, regardless of auxological and hormonal parameters. Therefore, prepubertal GHD females should probably need a more proper monitoring in clinical practice.http://www.endocrineconnections.com/content/7/7/879.fullgrowth hormonegenderchildreninsulin sensitivitymetabolism |
| spellingShingle | Alessandro Ciresi Stefano Radellini Valentina Guarnotta Maria Grazia Mineo Carla Giordano The metabolic outcomes of growth hormone treatment in children are gender specific Endocrine Connections growth hormone gender children insulin sensitivity metabolism |
| title | The metabolic outcomes of growth hormone treatment in children are gender specific |
| title_full | The metabolic outcomes of growth hormone treatment in children are gender specific |
| title_fullStr | The metabolic outcomes of growth hormone treatment in children are gender specific |
| title_full_unstemmed | The metabolic outcomes of growth hormone treatment in children are gender specific |
| title_short | The metabolic outcomes of growth hormone treatment in children are gender specific |
| title_sort | metabolic outcomes of growth hormone treatment in children are gender specific |
| topic | growth hormone gender children insulin sensitivity metabolism |
| url | http://www.endocrineconnections.com/content/7/7/879.full |
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