Postoperative remote lung injury and its impact on surgical outcome
Abstract Postoperative remote lung injury is a complication following various surgeries and is associated with short and long-term mortality and morbidity. The release of proinflammatory cytokines, damage-associated molecular patterns such as high-mobility group box-1, nucleotide-biding oligomerizat...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-03-01
|
| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12871-019-0698-6 |
| _version_ | 1818198959266463744 |
|---|---|
| author | Lin Chen Hailin Zhao Azeem Alam Emma Mi Shiori Eguchi Shanglong Yao Daqing Ma |
| author_facet | Lin Chen Hailin Zhao Azeem Alam Emma Mi Shiori Eguchi Shanglong Yao Daqing Ma |
| author_sort | Lin Chen |
| collection | DOAJ |
| description | Abstract Postoperative remote lung injury is a complication following various surgeries and is associated with short and long-term mortality and morbidity. The release of proinflammatory cytokines, damage-associated molecular patterns such as high-mobility group box-1, nucleotide-biding oligomerization domain (NOD)-like receptor protein 3 and heat shock protein, and cell death signalling activation, trigger a systemic inflammatory response, which ultimately results in organ injury including lung injury. Except high financial burden, the outcome of patients developing postoperative remote lung injury is often not optimistic. Several risk factors had been classified to predict the occurrence of postoperative remote lung injury, while lung protective ventilation and other strategies may confer protective effect against it. Understanding the pathophysiology of this process will facilitate the design of novel therapeutic strategies and promote better outcomes of surgical patients. This review discusses the cause and pathology underlying postoperative remote lung injury. Risk factors, surgical outcomes and potential preventative/treatment strategies against postoperative remote lung injury are also addressed. |
| first_indexed | 2024-12-12T02:14:09Z |
| format | Article |
| id | doaj.art-3fc4726cc1724d29828cfba966ef1623 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-12T02:14:09Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-3fc4726cc1724d29828cfba966ef16232022-12-22T00:41:49ZengBMCBMC Anesthesiology1471-22532019-03-0119111010.1186/s12871-019-0698-6Postoperative remote lung injury and its impact on surgical outcomeLin Chen0Hailin Zhao1Azeem Alam2Emma Mi3Shiori Eguchi4Shanglong Yao5Daqing Ma6Department of Anaesthesiology, Institute of Anaesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster HospitalAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster HospitalAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster HospitalAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster HospitalDepartment of Anaesthesiology, Institute of Anaesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAnaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster HospitalAbstract Postoperative remote lung injury is a complication following various surgeries and is associated with short and long-term mortality and morbidity. The release of proinflammatory cytokines, damage-associated molecular patterns such as high-mobility group box-1, nucleotide-biding oligomerization domain (NOD)-like receptor protein 3 and heat shock protein, and cell death signalling activation, trigger a systemic inflammatory response, which ultimately results in organ injury including lung injury. Except high financial burden, the outcome of patients developing postoperative remote lung injury is often not optimistic. Several risk factors had been classified to predict the occurrence of postoperative remote lung injury, while lung protective ventilation and other strategies may confer protective effect against it. Understanding the pathophysiology of this process will facilitate the design of novel therapeutic strategies and promote better outcomes of surgical patients. This review discusses the cause and pathology underlying postoperative remote lung injury. Risk factors, surgical outcomes and potential preventative/treatment strategies against postoperative remote lung injury are also addressed.http://link.springer.com/article/10.1186/s12871-019-0698-6Remote lung injuryCytokinePathophysiologyRisk factorTherapeutic strategy |
| spellingShingle | Lin Chen Hailin Zhao Azeem Alam Emma Mi Shiori Eguchi Shanglong Yao Daqing Ma Postoperative remote lung injury and its impact on surgical outcome BMC Anesthesiology Remote lung injury Cytokine Pathophysiology Risk factor Therapeutic strategy |
| title | Postoperative remote lung injury and its impact on surgical outcome |
| title_full | Postoperative remote lung injury and its impact on surgical outcome |
| title_fullStr | Postoperative remote lung injury and its impact on surgical outcome |
| title_full_unstemmed | Postoperative remote lung injury and its impact on surgical outcome |
| title_short | Postoperative remote lung injury and its impact on surgical outcome |
| title_sort | postoperative remote lung injury and its impact on surgical outcome |
| topic | Remote lung injury Cytokine Pathophysiology Risk factor Therapeutic strategy |
| url | http://link.springer.com/article/10.1186/s12871-019-0698-6 |
| work_keys_str_mv | AT linchen postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT hailinzhao postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT azeemalam postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT emmami postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT shiorieguchi postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT shanglongyao postoperativeremotelunginjuryanditsimpactonsurgicaloutcome AT daqingma postoperativeremotelunginjuryanditsimpactonsurgicaloutcome |