Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved]
The dentate gyrus continually produces new neurons throughout life. Behavioral studies in rodents and network models show that new neurons contribute to normal dentate functions, but there are many unanswered questions about how the relatively small population of new neurons alters network activity....
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-11-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/8-1998/v1 |
| _version_ | 1819085945719226368 |
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| author | Cristina V. Dieni Jose Carlos Gonzalez Linda Overstreet-Wadiche |
| author_facet | Cristina V. Dieni Jose Carlos Gonzalez Linda Overstreet-Wadiche |
| author_sort | Cristina V. Dieni |
| collection | DOAJ |
| description | The dentate gyrus continually produces new neurons throughout life. Behavioral studies in rodents and network models show that new neurons contribute to normal dentate functions, but there are many unanswered questions about how the relatively small population of new neurons alters network activity. Here we discuss experimental evidence that supports multiple cellular mechanisms by which adult-born neurons contribute to circuit function. Whereas past work focused on the unique intrinsic properties of young neurons, more recent studies also suggest that adult-born neurons alter the excitability of the mature neuronal population via unexpected circuit interactions. |
| first_indexed | 2024-12-21T21:12:25Z |
| format | Article |
| id | doaj.art-3fc5924a19644411ae60ab2c2297558e |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T21:12:25Z |
| publishDate | 2019-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-3fc5924a19644411ae60ab2c2297558e2022-12-21T18:50:05ZengF1000 Research LtdF1000Research2046-14022019-11-01810.12688/f1000research.20642.122703Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved]Cristina V. Dieni0Jose Carlos Gonzalez1Linda Overstreet-Wadiche2Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USADepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USAThe dentate gyrus continually produces new neurons throughout life. Behavioral studies in rodents and network models show that new neurons contribute to normal dentate functions, but there are many unanswered questions about how the relatively small population of new neurons alters network activity. Here we discuss experimental evidence that supports multiple cellular mechanisms by which adult-born neurons contribute to circuit function. Whereas past work focused on the unique intrinsic properties of young neurons, more recent studies also suggest that adult-born neurons alter the excitability of the mature neuronal population via unexpected circuit interactions.https://f1000research.com/articles/8-1998/v1 |
| spellingShingle | Cristina V. Dieni Jose Carlos Gonzalez Linda Overstreet-Wadiche Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] F1000Research |
| title | Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] |
| title_full | Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] |
| title_fullStr | Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] |
| title_full_unstemmed | Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] |
| title_short | Multifaceted circuit functions of adult-born neurons [version 1; peer review: 4 approved] |
| title_sort | multifaceted circuit functions of adult born neurons version 1 peer review 4 approved |
| url | https://f1000research.com/articles/8-1998/v1 |
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