New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico
One recurring difficulty in ecotoxicological studies is that a substantial portion of concentrations are below the limits of detection established by analytical laboratories. This results in censored distributions in which concentrations of some samples are only known to be below a threshold. The cu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/21/2919 |
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| author | Inmaculada Salvat-Leal Adriana A. Cortés-Gómez Diego Romero Marc Girondot |
| author_facet | Inmaculada Salvat-Leal Adriana A. Cortés-Gómez Diego Romero Marc Girondot |
| author_sort | Inmaculada Salvat-Leal |
| collection | DOAJ |
| description | One recurring difficulty in ecotoxicological studies is that a substantial portion of concentrations are below the limits of detection established by analytical laboratories. This results in censored distributions in which concentrations of some samples are only known to be below a threshold. The currently available methods have several limitations because they cannot be used with complex situations (e.g., different lower and upper limits in the same dataset, mixture of distributions, truncation and censoring in a single dataset). We propose a versatile method to fit the most diverse situations using conditional likelihood and Bayesian statistics. We test the method with a fictive dataset to ensure its correct description of a known situation. Then we apply the method to a dataset comprising 25 element concentrations analyzed in the blood of nesting marine turtles. We confirm previous findings using this dataset, and we also detect an unexpected new relationship between mortality and strontium concentration. |
| first_indexed | 2024-03-09T19:20:54Z |
| format | Article |
| id | doaj.art-3fc7ae7fccde415b813ee85dd63c1311 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T19:20:54Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-3fc7ae7fccde415b813ee85dd63c13112023-11-24T03:23:49ZengMDPI AGAnimals2076-26152022-10-011221291910.3390/ani12212919New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from MexicoInmaculada Salvat-Leal0Adriana A. Cortés-Gómez1Diego Romero2Marc Girondot3Toxicology Area, Faculty of Veterinary Medicine, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia, Espinardo, 30100 Murcia, SpainLaboratory Ecologie Systématique et Evolution, Université Paris-Saclay, CNRS, AgroParisTech, 91190 Gif-sur-Yvette, FranceToxicology Area, Faculty of Veterinary Medicine, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia, Espinardo, 30100 Murcia, SpainLaboratory Ecologie Systématique et Evolution, Université Paris-Saclay, CNRS, AgroParisTech, 91190 Gif-sur-Yvette, FranceOne recurring difficulty in ecotoxicological studies is that a substantial portion of concentrations are below the limits of detection established by analytical laboratories. This results in censored distributions in which concentrations of some samples are only known to be below a threshold. The currently available methods have several limitations because they cannot be used with complex situations (e.g., different lower and upper limits in the same dataset, mixture of distributions, truncation and censoring in a single dataset). We propose a versatile method to fit the most diverse situations using conditional likelihood and Bayesian statistics. We test the method with a fictive dataset to ensure its correct description of a known situation. Then we apply the method to a dataset comprising 25 element concentrations analyzed in the blood of nesting marine turtles. We confirm previous findings using this dataset, and we also detect an unexpected new relationship between mortality and strontium concentration.https://www.mdpi.com/2076-2615/12/21/2919detection limitBayesian modelcensored distributiontruncated distribution |
| spellingShingle | Inmaculada Salvat-Leal Adriana A. Cortés-Gómez Diego Romero Marc Girondot New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico Animals detection limit Bayesian model censored distribution truncated distribution |
| title | New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico |
| title_full | New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico |
| title_fullStr | New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico |
| title_full_unstemmed | New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico |
| title_short | New Method for Imputation of Unquantifiable Values Using Bayesian Statistics for a Mixture of Censored or Truncated Distributions: Application to Trace Elements Measured in Blood of Olive Ridley Sea Turtles from Mexico |
| title_sort | new method for imputation of unquantifiable values using bayesian statistics for a mixture of censored or truncated distributions application to trace elements measured in blood of olive ridley sea turtles from mexico |
| topic | detection limit Bayesian model censored distribution truncated distribution |
| url | https://www.mdpi.com/2076-2615/12/21/2919 |
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