Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth
Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate’s origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby G...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/916 |
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| author | Laurentya Olga Janna A. van Diepen Maciej Chichlowski Clive J. Petry Jacques Vervoort David B. Dunger Guus A. M. Kortman Gabriele Gross Ken K. Ong |
| author_facet | Laurentya Olga Janna A. van Diepen Maciej Chichlowski Clive J. Petry Jacques Vervoort David B. Dunger Guus A. M. Kortman Gabriele Gross Ken K. Ong |
| author_sort | Laurentya Olga |
| collection | DOAJ |
| description | Butyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate’s origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby Growth and Breastfeeding Study (CBGS-BF), in which infants (<i>n</i> = 59) were exclusively breastfed for at least 6 weeks. Infant growth (birth, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months) and HM butyrate concentrations (2 weeks, 6 weeks, 3 months, and 6 months) were measured. At age 6 weeks, HM intake volume was measured by deuterium-labelled water technique and HM microbiota by 16S sequencing. Cross-sectionally at 6 weeks, HM butyrate was associated with HM microbiota composition (<i>p</i> = 0.036) although no association with the abundance of typical butyrate producers was detected. In longitudinal analyses across all time points, HM butyrate concentrations were overall negatively associated with infant weight and adiposity, and associations were stronger at younger infant ages. HM butyrate concentration was also inversely correlated with HM intake volume, supporting a possible mechanism whereby butyrate might reduce infant growth via appetite regulation and modulation of HM intake. |
| first_indexed | 2024-03-11T08:19:45Z |
| format | Article |
| id | doaj.art-3fc93317ef634cd48f42abb1070f6adc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:19:45Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3fc93317ef634cd48f42abb1070f6adc2023-11-16T22:30:43ZengMDPI AGNutrients2072-66432023-02-0115491610.3390/nu15040916Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant GrowthLaurentya Olga0Janna A. van Diepen1Maciej Chichlowski2Clive J. Petry3Jacques Vervoort4David B. Dunger5Guus A. M. Kortman6Gabriele Gross7Ken K. Ong8Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UKMedical and Scientific Affairs, Reckitt/Mead Johnson Nutrition Institute, Evansville, IN 47721, USAMedical and Scientific Affairs, Reckitt/Mead Johnson Nutrition Institute, Evansville, IN 47721, USADepartment of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Agrotechnology and Food Sciences, Wageningen University, 6708 WE Wageningen, The NetherlandsDepartment of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UKNIZO Food Research BV, 6718 ZB Ede, The NetherlandsMedical and Scientific Affairs, Reckitt/Mead Johnson Nutrition Institute, Evansville, IN 47721, USADepartment of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UKButyrate in human milk (HM) has been suggested to reduce excessive weight and adipo-sity gains during infancy. However, HM butyrate’s origins, determinants, and its influencing mechanism on weight gain are not completely understood. These were studied in the prospective longitudinal Cambridge Baby Growth and Breastfeeding Study (CBGS-BF), in which infants (<i>n</i> = 59) were exclusively breastfed for at least 6 weeks. Infant growth (birth, 2 weeks, 6 weeks, 3 months, 6 months, and 12 months) and HM butyrate concentrations (2 weeks, 6 weeks, 3 months, and 6 months) were measured. At age 6 weeks, HM intake volume was measured by deuterium-labelled water technique and HM microbiota by 16S sequencing. Cross-sectionally at 6 weeks, HM butyrate was associated with HM microbiota composition (<i>p</i> = 0.036) although no association with the abundance of typical butyrate producers was detected. In longitudinal analyses across all time points, HM butyrate concentrations were overall negatively associated with infant weight and adiposity, and associations were stronger at younger infant ages. HM butyrate concentration was also inversely correlated with HM intake volume, supporting a possible mechanism whereby butyrate might reduce infant growth via appetite regulation and modulation of HM intake.https://www.mdpi.com/2072-6643/15/4/916human milk butyratehuman milk microbiotahuman milk intake volumebutyrate intakeinfant growthinfant adiposity |
| spellingShingle | Laurentya Olga Janna A. van Diepen Maciej Chichlowski Clive J. Petry Jacques Vervoort David B. Dunger Guus A. M. Kortman Gabriele Gross Ken K. Ong Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth Nutrients human milk butyrate human milk microbiota human milk intake volume butyrate intake infant growth infant adiposity |
| title | Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth |
| title_full | Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth |
| title_fullStr | Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth |
| title_full_unstemmed | Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth |
| title_short | Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth |
| title_sort | butyrate in human milk associations with milk microbiota milk intake volume and infant growth |
| topic | human milk butyrate human milk microbiota human milk intake volume butyrate intake infant growth infant adiposity |
| url | https://www.mdpi.com/2072-6643/15/4/916 |
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