Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors

Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors

Arrestins are a small family of proteins that bind G protein-coupled receptors (GPCRs). Arrestin binds to active phosphorylated GPCRs with higher affinity than to all other functional forms of the receptor, including inactive phosphorylated and active unphosphorylated. The selectivity of arrestins s...

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Bibliographic Details
Main Authors: Preethi C. Karnam, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
arrestin
GPCR
phosphorylation
selectivity
structure–function
Online Access:https://www.mdpi.com/1422-0067/22/22/12481

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