The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis.
<h4>Background</h4>The Xeroderma pigmento-sum group D gene (XPD) plays a key role in nucleotide excision repair. Single nucleotide polymorphisms (SNP) located in its functional region may alter DNA repair capacity phenotype and cancer risk. Many studies have demonstrated that XPD polymor...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096301&type=printable |
| _version_ | 1826587218316099584 |
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| author | Haina Du Nannan Guo Bin Shi Qian Zhang Zhipeng Chen Kai Lu Yongqian Shu Tao Chen Lingjun Zhu |
| author_facet | Haina Du Nannan Guo Bin Shi Qian Zhang Zhipeng Chen Kai Lu Yongqian Shu Tao Chen Lingjun Zhu |
| author_sort | Haina Du |
| collection | DOAJ |
| description | <h4>Background</h4>The Xeroderma pigmento-sum group D gene (XPD) plays a key role in nucleotide excision repair. Single nucleotide polymorphisms (SNP) located in its functional region may alter DNA repair capacity phenotype and cancer risk. Many studies have demonstrated that XPD polymorphisms are significantly associated with digestive tract cancers risk, but the results are inconsistent. We conducted a comprehensive meta-analysis to assess the association between XPD Lys751Gln polymorphism and digestive tract cancers risk. The digestive tract cancers that our study referred to, includes oral cancer, esophageal cancer, gastric cancer and colorectal cancer.<h4>Methods</h4>We searched PubMed and EmBase up to December 31, 2012 to identify eligible studies. A total of 37 case-control studies including 9027 cases and 16072 controls were involved in this meta-analysis. Statistical analyses were performed with Stata software (version 11.0, USA). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.<h4>Results</h4>The results showed that XPD Lys751Gln polymorphism was associated with the increased risk of digestive tract cancers (homozygote comparison (GlnGln vs. LysLys): OR = 1.12, 95% CI = 1.01-1.24, P = 0.029, P heterogeneity = 0.133). We found no statistical evidence for a significantly increased digestive tract cancers risk in the other genetic models. In the subgroup analysis, we also found the homozygote comparison increased the susceptibility of Asian population (OR = 1.28, 95% CI = 1.01-1.63, P = 0.045, P heterogeneity = 0.287). Stratified by cancer type and source of control, no significantly increased cancer risk was found in these subgroups. Additionally, risk estimates from hospital-based studies and esophageal studies were heterogeneous.<h4>Conclusions</h4>Our meta-analysis suggested that the XPD 751Gln/Gln genotype was a low-penetrate risk factor for developing digestive tract cancers, especially in Asian populations. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2025-03-14T16:21:56Z |
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| spelling | doaj.art-3fcbfbdc12b14561b2aabe1c12f231fd2025-02-22T05:33:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9630110.1371/journal.pone.0096301The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis.Haina DuNannan GuoBin ShiQian ZhangZhipeng ChenKai LuYongqian ShuTao ChenLingjun Zhu<h4>Background</h4>The Xeroderma pigmento-sum group D gene (XPD) plays a key role in nucleotide excision repair. Single nucleotide polymorphisms (SNP) located in its functional region may alter DNA repair capacity phenotype and cancer risk. Many studies have demonstrated that XPD polymorphisms are significantly associated with digestive tract cancers risk, but the results are inconsistent. We conducted a comprehensive meta-analysis to assess the association between XPD Lys751Gln polymorphism and digestive tract cancers risk. The digestive tract cancers that our study referred to, includes oral cancer, esophageal cancer, gastric cancer and colorectal cancer.<h4>Methods</h4>We searched PubMed and EmBase up to December 31, 2012 to identify eligible studies. A total of 37 case-control studies including 9027 cases and 16072 controls were involved in this meta-analysis. Statistical analyses were performed with Stata software (version 11.0, USA). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association.<h4>Results</h4>The results showed that XPD Lys751Gln polymorphism was associated with the increased risk of digestive tract cancers (homozygote comparison (GlnGln vs. LysLys): OR = 1.12, 95% CI = 1.01-1.24, P = 0.029, P heterogeneity = 0.133). We found no statistical evidence for a significantly increased digestive tract cancers risk in the other genetic models. In the subgroup analysis, we also found the homozygote comparison increased the susceptibility of Asian population (OR = 1.28, 95% CI = 1.01-1.63, P = 0.045, P heterogeneity = 0.287). Stratified by cancer type and source of control, no significantly increased cancer risk was found in these subgroups. Additionally, risk estimates from hospital-based studies and esophageal studies were heterogeneous.<h4>Conclusions</h4>Our meta-analysis suggested that the XPD 751Gln/Gln genotype was a low-penetrate risk factor for developing digestive tract cancers, especially in Asian populations.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096301&type=printable |
| spellingShingle | Haina Du Nannan Guo Bin Shi Qian Zhang Zhipeng Chen Kai Lu Yongqian Shu Tao Chen Lingjun Zhu The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. PLoS ONE |
| title | The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. |
| title_full | The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. |
| title_fullStr | The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. |
| title_full_unstemmed | The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. |
| title_short | The effect of XPD polymorphisms on digestive tract cancers risk: a meta-analysis. |
| title_sort | effect of xpd polymorphisms on digestive tract cancers risk a meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096301&type=printable |
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