Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia
The thresholds of macular microvasculature parameters associated with mild visual impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this prospective observational study is aimed at demonstrating the optical coherence tomography angiography parameters that best correlate...
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1050 |
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| author | Wei-Shan Tsai Sridevi Thottarath Sarega Gurudas Piyali Sen Elizabeth Pearce Andrea Giani Victor Chong Chui Ming Gemmy Cheung Sobha Sivaprasad |
| author_facet | Wei-Shan Tsai Sridevi Thottarath Sarega Gurudas Piyali Sen Elizabeth Pearce Andrea Giani Victor Chong Chui Ming Gemmy Cheung Sobha Sivaprasad |
| author_sort | Wei-Shan Tsai |
| collection | DOAJ |
| description | The thresholds of macular microvasculature parameters associated with mild visual impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this prospective observational study is aimed at demonstrating the optical coherence tomography angiography parameters that best correlate with mild visual impairment (<70 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, Snellen equivalent 20/40) in DMI. The study was completed at the Moorfields Eye Hospital from December 2019 to August 2021. A total of 123 eyes of 87 patients with stable-treated proliferative diabetic retinopathy following panretinal photocoagulation were recruited. DMI was defined as an irregular foveal avascular zone (FAZ) area ≥ 0.5 mm<sup>2</sup> or a smaller FAZ area with parafoveal capillary dropout in at least one quadrant. The analysis showed that the whole image deep vascular complex vessel density (DVC VD) in the 3 × 3 mm area had the best discriminatory ability to identify participants with mild visual impairment at 41.9% (area under the curve = 0.77, sensitivity 94%, specificity 54%, likelihood ratio [LR] = 2.04), and the FAZ area had the greatest post-test LR = 4.21 at 0.64 mm<sup>2</sup>. The 3 × 3 mm whole image DVC VD and FAZ area cutoffs are useful for screening vision-threatening DMI, but DVC VD has low specificity. |
| first_indexed | 2024-03-10T03:03:40Z |
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| id | doaj.art-3fcc95cf23574ff5983613e75262360a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:03:40Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-3fcc95cf23574ff5983613e75262360a2023-11-23T10:38:36ZengMDPI AGDiagnostics2075-44182022-04-01125105010.3390/diagnostics12051050Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular IschemiaWei-Shan Tsai0Sridevi Thottarath1Sarega Gurudas2Piyali Sen3Elizabeth Pearce4Andrea Giani5Victor Chong6Chui Ming Gemmy Cheung7Sobha Sivaprasad8NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London EC1V 2PD, UKNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London EC1V 2PD, UKInstitute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UKInstitute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UKBoehringer Ingelheim, Binger Street 173, 55218 Ingelheim am Rhein, GermanyBoehringer Ingelheim, Binger Street 173, 55218 Ingelheim am Rhein, GermanyInstitute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UKSingapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751, SingaporeNIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London EC1V 2PD, UKThe thresholds of macular microvasculature parameters associated with mild visual impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this prospective observational study is aimed at demonstrating the optical coherence tomography angiography parameters that best correlate with mild visual impairment (<70 Early Treatment Diabetic Retinopathy Study (ETDRS) letters, Snellen equivalent 20/40) in DMI. The study was completed at the Moorfields Eye Hospital from December 2019 to August 2021. A total of 123 eyes of 87 patients with stable-treated proliferative diabetic retinopathy following panretinal photocoagulation were recruited. DMI was defined as an irregular foveal avascular zone (FAZ) area ≥ 0.5 mm<sup>2</sup> or a smaller FAZ area with parafoveal capillary dropout in at least one quadrant. The analysis showed that the whole image deep vascular complex vessel density (DVC VD) in the 3 × 3 mm area had the best discriminatory ability to identify participants with mild visual impairment at 41.9% (area under the curve = 0.77, sensitivity 94%, specificity 54%, likelihood ratio [LR] = 2.04), and the FAZ area had the greatest post-test LR = 4.21 at 0.64 mm<sup>2</sup>. The 3 × 3 mm whole image DVC VD and FAZ area cutoffs are useful for screening vision-threatening DMI, but DVC VD has low specificity.https://www.mdpi.com/2075-4418/12/5/1050diabetic macular ischemiaoptical coherence tomography angiographyvisual acuitylow-luminance visual acuityproliferative diabetic retinopathypanretinal photocoagulation |
| spellingShingle | Wei-Shan Tsai Sridevi Thottarath Sarega Gurudas Piyali Sen Elizabeth Pearce Andrea Giani Victor Chong Chui Ming Gemmy Cheung Sobha Sivaprasad Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia Diagnostics diabetic macular ischemia optical coherence tomography angiography visual acuity low-luminance visual acuity proliferative diabetic retinopathy panretinal photocoagulation |
| title | Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia |
| title_full | Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia |
| title_fullStr | Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia |
| title_full_unstemmed | Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia |
| title_short | Correlation of Optical Coherence Tomography Angiography Characteristics with Visual Function to Define Vision-Threatening Diabetic Macular Ischemia |
| title_sort | correlation of optical coherence tomography angiography characteristics with visual function to define vision threatening diabetic macular ischemia |
| topic | diabetic macular ischemia optical coherence tomography angiography visual acuity low-luminance visual acuity proliferative diabetic retinopathy panretinal photocoagulation |
| url | https://www.mdpi.com/2075-4418/12/5/1050 |
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