Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening
Ambient ionization mass spectrometry has become one of the most promising approaches for rapid and high-throughput screening of small molecules in complex biological matrices for emergency medicine, forensics, and food and agriculture applications. The simple procedures for sample collection and ion...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/3/945 |
| _version_ | 1797486019999694848 |
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| author | Mariya A. Shamraeva Denis S. Bormotov Ekaterina V. Shamarina Konstantin V. Bocharov Olga V. Peregudova Stanislav I. Pekov Eugene N. Nikolaev Igor A. Popov |
| author_facet | Mariya A. Shamraeva Denis S. Bormotov Ekaterina V. Shamarina Konstantin V. Bocharov Olga V. Peregudova Stanislav I. Pekov Eugene N. Nikolaev Igor A. Popov |
| author_sort | Mariya A. Shamraeva |
| collection | DOAJ |
| description | Ambient ionization mass spectrometry has become one of the most promising approaches for rapid and high-throughput screening of small molecules in complex biological matrices for emergency medicine, forensics, and food and agriculture applications. The simple procedures for sample collection and ionization without additional pretreatment are vital in these fields. Many efforts have been devoted to modifying various ambient ionization techniques to simplify the procedures and improve the robustness and sensitivity of the methods. Here, we demonstrate the implementation of rigid spherical sampler probes to improve the robustness of touch spray ionization mass spectrometry. The sphericity of the probes increases the stability of the cone-jet mode of electrospray, reduces the requirements for fine positioning of a sampler in the ion source, and decreases the possibility of corona discharge occurrence. The utilization of spherical sampler probes allows fast, non-invasive sampling, followed by rapid analysis for various drugs of different chemical classes in complex biological matrices, such as the whole blood or sebum collected from the skin surface. The linearity of the analytical signal response from drug concentration confirms the possibility of creating a simple semiquantitative method for small molecules monitoring using spherical sampler probes. |
| first_indexed | 2024-03-09T23:27:12Z |
| format | Article |
| id | doaj.art-3fce852341a34858ac51e4d80e7d84a6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:27:12Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3fce852341a34858ac51e4d80e7d84a62023-11-23T17:15:04ZengMDPI AGMolecules1420-30492022-01-0127394510.3390/molecules27030945Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs ScreeningMariya A. Shamraeva0Denis S. Bormotov1Ekaterina V. Shamarina2Konstantin V. Bocharov3Olga V. Peregudova4Stanislav I. Pekov5Eugene N. Nikolaev6Igor A. Popov7Moscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaV. L. Talrose Institute for Energy Problems of Chemical Physics, N. N. Semenov Federal Center of Chemical Physics, Russian Academy of Sciences, 119334 Moscow, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaSkolkovo Institute of Science and Technology, 121205 Moscow, RussiaSkolkovo Institute of Science and Technology, 121205 Moscow, RussiaMoscow Institute of Physics and Technology, 141701 Dolgoprudny, RussiaAmbient ionization mass spectrometry has become one of the most promising approaches for rapid and high-throughput screening of small molecules in complex biological matrices for emergency medicine, forensics, and food and agriculture applications. The simple procedures for sample collection and ionization without additional pretreatment are vital in these fields. Many efforts have been devoted to modifying various ambient ionization techniques to simplify the procedures and improve the robustness and sensitivity of the methods. Here, we demonstrate the implementation of rigid spherical sampler probes to improve the robustness of touch spray ionization mass spectrometry. The sphericity of the probes increases the stability of the cone-jet mode of electrospray, reduces the requirements for fine positioning of a sampler in the ion source, and decreases the possibility of corona discharge occurrence. The utilization of spherical sampler probes allows fast, non-invasive sampling, followed by rapid analysis for various drugs of different chemical classes in complex biological matrices, such as the whole blood or sebum collected from the skin surface. The linearity of the analytical signal response from drug concentration confirms the possibility of creating a simple semiquantitative method for small molecules monitoring using spherical sampler probes.https://www.mdpi.com/1420-3049/27/3/945mass spectrometryambient ionizationdrug monitoringemergency roomtouch spray ionizationmultiple compounds detection |
| spellingShingle | Mariya A. Shamraeva Denis S. Bormotov Ekaterina V. Shamarina Konstantin V. Bocharov Olga V. Peregudova Stanislav I. Pekov Eugene N. Nikolaev Igor A. Popov Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening Molecules mass spectrometry ambient ionization drug monitoring emergency room touch spray ionization multiple compounds detection |
| title | Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening |
| title_full | Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening |
| title_fullStr | Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening |
| title_full_unstemmed | Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening |
| title_short | Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening |
| title_sort | spherical sampler probes enhance the robustness of ambient ionization mass spectrometry for rapid drugs screening |
| topic | mass spectrometry ambient ionization drug monitoring emergency room touch spray ionization multiple compounds detection |
| url | https://www.mdpi.com/1420-3049/27/3/945 |
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