Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study.
<h4>Objectives</h4>Low 25(OH)D has been associated with dyslipidemia, insulin resistance and inflammation in both general and HIV-infected (mostly treated) populations. We investigated these associations in antiretroviral-naïve HIV-infected persons.<h4>Design</h4>We measured...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24058636/?tool=EBI |
| _version_ | 1818701702271860736 |
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| author | Camille Legeai Corinne Vigouroux Jean-Claude Souberbielle Olivier Bouchaud Faroudy Boufassa Jean-Philippe Bastard Robert Carlier Jacqueline Capeau Cécile Goujard Laurence Meyer Jean-Paul Viard ANRS-COPANA Cohort Study Group |
| author_facet | Camille Legeai Corinne Vigouroux Jean-Claude Souberbielle Olivier Bouchaud Faroudy Boufassa Jean-Philippe Bastard Robert Carlier Jacqueline Capeau Cécile Goujard Laurence Meyer Jean-Paul Viard ANRS-COPANA Cohort Study Group |
| author_sort | Camille Legeai |
| collection | DOAJ |
| description | <h4>Objectives</h4>Low 25(OH)D has been associated with dyslipidemia, insulin resistance and inflammation in both general and HIV-infected (mostly treated) populations. We investigated these associations in antiretroviral-naïve HIV-infected persons.<h4>Design</h4>We measured plasma 25(OH)D, metabolic, immunologic and inflammatory markers in 355 persons (204 Whites, 151 Blacks) at enrollment in the ANRS COPANA cohort.<h4>Methods</h4>25(OH)D levels were categorized <10 ng/mL (severe deficiency) and <20 ng/mL (deficiency). Statistical analyses were adjusted for sampling season, ethnicity and the interaction between season and ethnicity.<h4>Results</h4>25(OH)D insufficiency (<30 ng/mL), deficiency (<20 ng/mL) and severe deficiency (<10 ng/mL) were highly prevalent (93%, 67% and 24% of patients, respectively). Blacks had significantly lower 25(OH)D than Whites (median: 13 vs. 17 ng/mL, P<0.001), with markedly less pronounced seasonal variation. Smoking and drinking alcohol were associated with having a 25 OHD level<10 ng/mL. In patients with 25(OH)D<10 ng/mL, the proportion of persons with a CD4 count<100/mm(3) was higher than in patients with 25(OH)D≥10 ng/mL (18.8% vs. 10.7%, P = 0.04). Persons with 25 OHD<10 ng/mL had higher levels of hsCRP (1.60 mg/L [IQR: 0.59-5.76] vs. 1.27 mg/L [0.58-3,39], P = 0.03) and resistin (16.81 ng/L [IQR: 13.82-25.74] vs. 11.56 ng/L [IQR: 8.87-20.46], P = 0.02), and, among Blacks only, sTNFR2 (2.92 ng/mL [2.31-4.13] vs. 2.67 ng/mL, [1.90-3.23], P = 0.04). The strength and significance of the association between CD4<100/mm(3) and 25 OHD<10 ng/mL were reduced after adjustment on sTNFR1, sTNFR2, and hsCRP levels. In multivariate analysis, a CD4 count <100/mm(3), resistin concentration and smoking were independently associated with 25(OH)D<10 ng/mL.<h4>Conclusions</h4>Severe vitamin D deficiency was associated with low CD4 counts and increased markers of inflammation in ARV-naïve HIV-infected persons. |
| first_indexed | 2024-12-17T15:25:02Z |
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| language | English |
| last_indexed | 2024-12-17T15:25:02Z |
| publishDate | 2013-01-01 |
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| spelling | doaj.art-3fcffd0125a64aff88157194fca97bfd2022-12-21T21:43:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7486810.1371/journal.pone.0074868Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study.Camille LegeaiCorinne VigourouxJean-Claude SouberbielleOlivier BouchaudFaroudy BoufassaJean-Philippe BastardRobert CarlierJacqueline CapeauCécile GoujardLaurence MeyerJean-Paul ViardANRS-COPANA Cohort Study Group<h4>Objectives</h4>Low 25(OH)D has been associated with dyslipidemia, insulin resistance and inflammation in both general and HIV-infected (mostly treated) populations. We investigated these associations in antiretroviral-naïve HIV-infected persons.<h4>Design</h4>We measured plasma 25(OH)D, metabolic, immunologic and inflammatory markers in 355 persons (204 Whites, 151 Blacks) at enrollment in the ANRS COPANA cohort.<h4>Methods</h4>25(OH)D levels were categorized <10 ng/mL (severe deficiency) and <20 ng/mL (deficiency). Statistical analyses were adjusted for sampling season, ethnicity and the interaction between season and ethnicity.<h4>Results</h4>25(OH)D insufficiency (<30 ng/mL), deficiency (<20 ng/mL) and severe deficiency (<10 ng/mL) were highly prevalent (93%, 67% and 24% of patients, respectively). Blacks had significantly lower 25(OH)D than Whites (median: 13 vs. 17 ng/mL, P<0.001), with markedly less pronounced seasonal variation. Smoking and drinking alcohol were associated with having a 25 OHD level<10 ng/mL. In patients with 25(OH)D<10 ng/mL, the proportion of persons with a CD4 count<100/mm(3) was higher than in patients with 25(OH)D≥10 ng/mL (18.8% vs. 10.7%, P = 0.04). Persons with 25 OHD<10 ng/mL had higher levels of hsCRP (1.60 mg/L [IQR: 0.59-5.76] vs. 1.27 mg/L [0.58-3,39], P = 0.03) and resistin (16.81 ng/L [IQR: 13.82-25.74] vs. 11.56 ng/L [IQR: 8.87-20.46], P = 0.02), and, among Blacks only, sTNFR2 (2.92 ng/mL [2.31-4.13] vs. 2.67 ng/mL, [1.90-3.23], P = 0.04). The strength and significance of the association between CD4<100/mm(3) and 25 OHD<10 ng/mL were reduced after adjustment on sTNFR1, sTNFR2, and hsCRP levels. In multivariate analysis, a CD4 count <100/mm(3), resistin concentration and smoking were independently associated with 25(OH)D<10 ng/mL.<h4>Conclusions</h4>Severe vitamin D deficiency was associated with low CD4 counts and increased markers of inflammation in ARV-naïve HIV-infected persons.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24058636/?tool=EBI |
| spellingShingle | Camille Legeai Corinne Vigouroux Jean-Claude Souberbielle Olivier Bouchaud Faroudy Boufassa Jean-Philippe Bastard Robert Carlier Jacqueline Capeau Cécile Goujard Laurence Meyer Jean-Paul Viard ANRS-COPANA Cohort Study Group Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. PLoS ONE |
| title | Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. |
| title_full | Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. |
| title_fullStr | Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. |
| title_full_unstemmed | Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. |
| title_short | Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: the ANRS CO9 «COPANA» cohort study. |
| title_sort | associations between 25 hydroxyvitamin d and immunologic metabolic inflammatory markers in treatment naive hiv infected persons the anrs co9 copana cohort study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24058636/?tool=EBI |
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