Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease
Both neopterin and biopterin concentrations in cerebrospinal fluid from patients with Parkinson's disease, in which the nigrostriatal dopamine neurons degenerate, were lower than those from age-matched older control subjects. However, the decrease in biopterin was more marked than that in neopt...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
1999-02-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines.1999.10.1.5 |
| _version_ | 1818873327262892032 |
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| author | Nagatsu T. Ichinose H. Mogi M. Togari A. |
| author_facet | Nagatsu T. Ichinose H. Mogi M. Togari A. |
| author_sort | Nagatsu T. |
| collection | DOAJ |
| description | Both neopterin and biopterin concentrations in cerebrospinal fluid from patients with Parkinson's disease, in which the nigrostriatal dopamine neurons degenerate, were lower than those from age-matched older control subjects. However, the decrease in biopterin was more marked than that in neopterin, resulting in the increase in the neopterin/ biopterin ratio in Parkinson's disease. These results suggests that neopterin in cerebrospinal fluid in Parkinson's disease may partly be derived from immunoactivated glial cells, besides catecholamine or serotonin n eurons including nigrostriatal dopamine neurons. In accordance to this hypothesis, cytokines (TNF-α, IL-1, IL-2 , IL-6, EGF, TGF-α, TGF-β1) were found to be increased in the striatum and/or in cerebrospinal fluid. The increment of cytokines in the brain in Parkinson's disease may be related to the mechanism of neurodegeneration of dopaminergic neurons in Parkinson's disease . In contrast to Parkinson's disease, in hereditary progressive dystonia/ dopa-responsive dystonia, which is a dopamine deficiency caused by mutations in GTP cyclohydrolase I without neuronal cell death (Segawa's disease), neopterin and biopterin in cerebrospinal fluid decreases in parallel owing to the decreased activity in GTP cyclohydrolase I . |
| first_indexed | 2024-12-19T12:52:56Z |
| format | Article |
| id | doaj.art-3fd19e36536e417990696473d315518a |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-19T12:52:56Z |
| publishDate | 1999-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-3fd19e36536e417990696473d315518a2022-12-21T20:20:29ZengDe GruyterPteridines0933-48072195-47201999-02-0110151310.1515/pteridines.1999.10.1.5Neopterin and Cytokines in Hereditary Dystonia and Parkinson's DiseaseNagatsu T.0Ichinose H.1Mogi M.2Togari A.3Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University,Toyoake, Aichi 470-1192, JapanDivision of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University,Toyoake, Aichi 470-1192, JapanDepartament of Pharmacology, School of Dentistry, Aichi -Gakuin University, Nagoya, JapanDepartament of Pharmacology, School of Dentistry, Aichi -Gakuin University, Nagoya, JapanBoth neopterin and biopterin concentrations in cerebrospinal fluid from patients with Parkinson's disease, in which the nigrostriatal dopamine neurons degenerate, were lower than those from age-matched older control subjects. However, the decrease in biopterin was more marked than that in neopterin, resulting in the increase in the neopterin/ biopterin ratio in Parkinson's disease. These results suggests that neopterin in cerebrospinal fluid in Parkinson's disease may partly be derived from immunoactivated glial cells, besides catecholamine or serotonin n eurons including nigrostriatal dopamine neurons. In accordance to this hypothesis, cytokines (TNF-α, IL-1, IL-2 , IL-6, EGF, TGF-α, TGF-β1) were found to be increased in the striatum and/or in cerebrospinal fluid. The increment of cytokines in the brain in Parkinson's disease may be related to the mechanism of neurodegeneration of dopaminergic neurons in Parkinson's disease . In contrast to Parkinson's disease, in hereditary progressive dystonia/ dopa-responsive dystonia, which is a dopamine deficiency caused by mutations in GTP cyclohydrolase I without neuronal cell death (Segawa's disease), neopterin and biopterin in cerebrospinal fluid decreases in parallel owing to the decreased activity in GTP cyclohydrolase I .https://doi.org/10.1515/pteridines.1999.10.1.5neopterincytokinescerebrospinal fluidstriatumparkinson's disease |
| spellingShingle | Nagatsu T. Ichinose H. Mogi M. Togari A. Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease Pteridines neopterin cytokines cerebrospinal fluid striatum parkinson's disease |
| title | Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease |
| title_full | Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease |
| title_fullStr | Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease |
| title_full_unstemmed | Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease |
| title_short | Neopterin and Cytokines in Hereditary Dystonia and Parkinson's Disease |
| title_sort | neopterin and cytokines in hereditary dystonia and parkinson s disease |
| topic | neopterin cytokines cerebrospinal fluid striatum parkinson's disease |
| url | https://doi.org/10.1515/pteridines.1999.10.1.5 |
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