Human induced pluripotent stem cells generated from a patient with a homozygous mutation in the Lyn kinase gene

Human induced pluripotent stem cells generated from a patient with a homozygous mutation in the Lyn kinase gene

We have successfully generated induced pluripotent stem cells (iPSC) from dermal fibroblasts of the patient with a germline mutation in the coding region of the LYN kinase gene. This gain of function (GOF) mutation eliminates the inhibitory tyrosine (Y) at the position p.Y508, with an unknown establ...

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Bibliographic Details
Main Authors:	Rebecca Harper, Quan Yu, Yangtenyu Liu, Dan Yang, Jizhong Zou, Jeanette Beers, Adriana A. de Jesus Rasheed, Raphaela Goldbach-Mansky, Manfred Boehm, Guibin Chen
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506122002823

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