Role of Vitamin K in Intestinal Health
Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC) generally characterized by clinical symptoms, including malabsorption, intestinal dysfunction, injury, and microbiome imbalance, as well as certain secondary intestinal disease complications, continue to be s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.791565/full |
| _version_ | 1798033971948290048 |
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| author | Yujiao Lai Hori Masatoshi Yanbo Ma Yuming Guo Bingkun Zhang |
| author_facet | Yujiao Lai Hori Masatoshi Yanbo Ma Yuming Guo Bingkun Zhang |
| author_sort | Yujiao Lai |
| collection | DOAJ |
| description | Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC) generally characterized by clinical symptoms, including malabsorption, intestinal dysfunction, injury, and microbiome imbalance, as well as certain secondary intestinal disease complications, continue to be serious public health problems worldwide. The role of vitamin K (VK) on intestinal health has drawn growing interest in recent years. In addition to its role in blood coagulation and bone health, several investigations continue to explore the role of VK as an emerging novel biological compound with the potential function of improving intestinal health. This study aims to present a thorough review on the bacterial sources, intestinal absorption, uptake of VK, and VK deficiency in patients with intestinal diseases, with emphasis on the effect of VK supplementation on immunity, anti-inflammation, intestinal microbes and its metabolites, antioxidation, and coagulation, and promoting epithelial development. Besides, VK-dependent proteins (VKDPs) are another crucial mechanism for VK to exert a gastroprotection role for their functions of anti-inflammation, immunomodulation, and anti-tumorigenesis. In summary, published studies preliminarily show that VK presents a beneficial effect on intestinal health and may be used as a therapeutic drug to prevent/treat intestinal diseases, but the specific mechanism of VK in intestinal health has yet to be elucidated. |
| first_indexed | 2024-04-11T20:36:54Z |
| format | Article |
| id | doaj.art-3fd5edd0823d495fb897ce53b3f1af22 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T20:36:54Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3fd5edd0823d495fb897ce53b3f1af222022-12-22T04:04:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.791565791565Role of Vitamin K in Intestinal HealthYujiao Lai0Hori Masatoshi1Yanbo Ma2Yuming Guo3Bingkun Zhang4State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, ChinaDepartment of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, JapanDepartment of Animal Physiology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, ChinaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, ChinaIntestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC) generally characterized by clinical symptoms, including malabsorption, intestinal dysfunction, injury, and microbiome imbalance, as well as certain secondary intestinal disease complications, continue to be serious public health problems worldwide. The role of vitamin K (VK) on intestinal health has drawn growing interest in recent years. In addition to its role in blood coagulation and bone health, several investigations continue to explore the role of VK as an emerging novel biological compound with the potential function of improving intestinal health. This study aims to present a thorough review on the bacterial sources, intestinal absorption, uptake of VK, and VK deficiency in patients with intestinal diseases, with emphasis on the effect of VK supplementation on immunity, anti-inflammation, intestinal microbes and its metabolites, antioxidation, and coagulation, and promoting epithelial development. Besides, VK-dependent proteins (VKDPs) are another crucial mechanism for VK to exert a gastroprotection role for their functions of anti-inflammation, immunomodulation, and anti-tumorigenesis. In summary, published studies preliminarily show that VK presents a beneficial effect on intestinal health and may be used as a therapeutic drug to prevent/treat intestinal diseases, but the specific mechanism of VK in intestinal health has yet to be elucidated.https://www.frontiersin.org/articles/10.3389/fimmu.2021.791565/fullVKintestinal healthVKDPsIBDsintestinal disease |
| spellingShingle | Yujiao Lai Hori Masatoshi Yanbo Ma Yuming Guo Bingkun Zhang Role of Vitamin K in Intestinal Health Frontiers in Immunology VK intestinal health VKDPs IBDs intestinal disease |
| title | Role of Vitamin K in Intestinal Health |
| title_full | Role of Vitamin K in Intestinal Health |
| title_fullStr | Role of Vitamin K in Intestinal Health |
| title_full_unstemmed | Role of Vitamin K in Intestinal Health |
| title_short | Role of Vitamin K in Intestinal Health |
| title_sort | role of vitamin k in intestinal health |
| topic | VK intestinal health VKDPs IBDs intestinal disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.791565/full |
| work_keys_str_mv | AT yujiaolai roleofvitaminkinintestinalhealth AT horimasatoshi roleofvitaminkinintestinalhealth AT yanboma roleofvitaminkinintestinalhealth AT yumingguo roleofvitaminkinintestinalhealth AT bingkunzhang roleofvitaminkinintestinalhealth |