Urinary tract infections and vitamin D: prospects for use in prevention and treatment
Urinary tract infections are a common global problem among physicians of various specialties, including therapists, pediatricians, nephrologists and urologists. Today UTI is one of the leading bacterial infections in both adult and child populations. The main type of therapy and prevention of rec...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2021-08-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6302 |
| _version_ | 1827962197406384128 |
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| author | I. N. Zakharova A. N. Tsutsaeva S. V. Dolbnya V. A. Kuryaninova L Ya. Klimov А. Ke. Minasyan D. V. Bobryshev A. I. Eryomenko |
| author_facet | I. N. Zakharova A. N. Tsutsaeva S. V. Dolbnya V. A. Kuryaninova L Ya. Klimov А. Ke. Minasyan D. V. Bobryshev A. I. Eryomenko |
| author_sort | I. N. Zakharova |
| collection | DOAJ |
| description | Urinary tract infections are a common global problem among physicians of various specialties, including therapists, pediatricians, nephrologists and urologists. Today UTI is one of the leading bacterial infections in both adult and child populations. The main type of therapy and prevention of recurrent UTI is the use of drugs with an antibacterial effect (antibiotics, uroseptics). An urgent problem in modern medical practice is the increasing antibiotic resistance, which requires the development of new approaches to therapy and prevention, including UTI. In recent years, special attention has been paid to the study of vitamin D receptor (VDR) gene polymorphisms as a possible risk factor determining the predisposition to a number of infectious and noninfectious diseases. More than 200 polymorphisms of the VDR gene have been identified, four of which – FokI, BsmI, ApaI, and TaqI – are particularly common. Different VDR alleles can cause small changes in receptor function, which can affect resistance or susceptibility to a particular infection. The review presents data from modern studies demonstrating the relationship between vitamin D supply and development, the frequency of recurrence and the nature of the course of UTI. In one study, vitamin D has been shown to enhance the cathelicidin-mediated antibacterial action of bladder epithelial cells. It also demonstrated the currently known defense mechanisms of vitamin D against urinary tract infections, including its effect on components of the innate immune system. |
| first_indexed | 2024-04-09T16:38:47Z |
| format | Article |
| id | doaj.art-3fdeb5c406854fff82834678df7f23dd |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:38:47Z |
| publishDate | 2021-08-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-3fdeb5c406854fff82834678df7f23dd2023-04-23T06:56:47ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-08-0101114815510.21518/2079-701X-2021-11-148-1555695Urinary tract infections and vitamin D: prospects for use in prevention and treatmentI. N. Zakharova0A. N. Tsutsaeva1S. V. Dolbnya2V. A. Kuryaninova3L Ya. Klimov4А. Ke. Minasyan5D. V. Bobryshev6A. I. Eryomenko7Russian Medical Academy of Continuous Profssional EducationStavropol State Medical University; Regional Children’s Clinical HospitalStavropol State Medical University; Regional Children’s Clinical HospitalStavropol State Medical University; Philippskiy City Children’s Clinical Hospital; SOGAZ International Medical CenterStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityStavropol State Medical UniversityUrinary tract infections are a common global problem among physicians of various specialties, including therapists, pediatricians, nephrologists and urologists. Today UTI is one of the leading bacterial infections in both adult and child populations. The main type of therapy and prevention of recurrent UTI is the use of drugs with an antibacterial effect (antibiotics, uroseptics). An urgent problem in modern medical practice is the increasing antibiotic resistance, which requires the development of new approaches to therapy and prevention, including UTI. In recent years, special attention has been paid to the study of vitamin D receptor (VDR) gene polymorphisms as a possible risk factor determining the predisposition to a number of infectious and noninfectious diseases. More than 200 polymorphisms of the VDR gene have been identified, four of which – FokI, BsmI, ApaI, and TaqI – are particularly common. Different VDR alleles can cause small changes in receptor function, which can affect resistance or susceptibility to a particular infection. The review presents data from modern studies demonstrating the relationship between vitamin D supply and development, the frequency of recurrence and the nature of the course of UTI. In one study, vitamin D has been shown to enhance the cathelicidin-mediated antibacterial action of bladder epithelial cells. It also demonstrated the currently known defense mechanisms of vitamin D against urinary tract infections, including its effect on components of the innate immune system.https://www.med-sovet.pro/jour/article/view/6302urinary tract infections, vitamin d, vitamin d deficiency, children, pregnant women, antimicrobial peptides |
| spellingShingle | I. N. Zakharova A. N. Tsutsaeva S. V. Dolbnya V. A. Kuryaninova L Ya. Klimov А. Ke. Minasyan D. V. Bobryshev A. I. Eryomenko Urinary tract infections and vitamin D: prospects for use in prevention and treatment Медицинский совет urinary tract infections, vitamin d, vitamin d deficiency, children, pregnant women, antimicrobial peptides |
| title | Urinary tract infections and vitamin D: prospects for use in prevention and treatment |
| title_full | Urinary tract infections and vitamin D: prospects for use in prevention and treatment |
| title_fullStr | Urinary tract infections and vitamin D: prospects for use in prevention and treatment |
| title_full_unstemmed | Urinary tract infections and vitamin D: prospects for use in prevention and treatment |
| title_short | Urinary tract infections and vitamin D: prospects for use in prevention and treatment |
| title_sort | urinary tract infections and vitamin d prospects for use in prevention and treatment |
| topic | urinary tract infections, vitamin d, vitamin d deficiency, children, pregnant women, antimicrobial peptides |
| url | https://www.med-sovet.pro/jour/article/view/6302 |
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