Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain
Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13696 |
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| author | Oxana Semyachkina-Glushkovskaya Sergey Sokolovski Ivan Fedosov Alexander Shirokov Nikita Navolokin Alla Bucharskaya Inna Blokhina Andrey Terskov Alexander Dubrovski Valeria Telnova Anna Tzven Maria Tzoy Arina Evsukova Daria Zhlatogosrkaya Viktoria Adushkina Alexander Dmitrenko Maria Manzhaeva Valeria Krupnova Alessio Noghero Denis Bragin Olga Bragina Ekaterina Borisova Jürgen Kurths Edik Rafailov |
| author_facet | Oxana Semyachkina-Glushkovskaya Sergey Sokolovski Ivan Fedosov Alexander Shirokov Nikita Navolokin Alla Bucharskaya Inna Blokhina Andrey Terskov Alexander Dubrovski Valeria Telnova Anna Tzven Maria Tzoy Arina Evsukova Daria Zhlatogosrkaya Viktoria Adushkina Alexander Dmitrenko Maria Manzhaeva Valeria Krupnova Alessio Noghero Denis Bragin Olga Bragina Ekaterina Borisova Jürgen Kurths Edik Rafailov |
| author_sort | Oxana Semyachkina-Glushkovskaya |
| collection | DOAJ |
| description | Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm<sup>2</sup> firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs. |
| first_indexed | 2024-03-10T22:41:06Z |
| format | Article |
| id | doaj.art-3fdec0125dc142889804d264cf8eb998 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:41:06Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3fdec0125dc142889804d264cf8eb9982023-11-19T11:01:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181369610.3390/ijms241813696Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat BrainOxana Semyachkina-Glushkovskaya0Sergey Sokolovski1Ivan Fedosov2Alexander Shirokov3Nikita Navolokin4Alla Bucharskaya5Inna Blokhina6Andrey Terskov7Alexander Dubrovski8Valeria Telnova9Anna Tzven10Maria Tzoy11Arina Evsukova12Daria Zhlatogosrkaya13Viktoria Adushkina14Alexander Dmitrenko15Maria Manzhaeva16Valeria Krupnova17Alessio Noghero18Denis Bragin19Olga Bragina20Ekaterina Borisova21Jürgen Kurths22Edik Rafailov23Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, GermanyOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham B4 7ET, UKPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Pathological Anatomy, Saratov Medical State University, Bolshaya Kazachaya Str. 112, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, RussiaLovelace Biomedical Research Institute, Albuquerque, NM 87108, USALovelace Biomedical Research Institute, Albuquerque, NM 87108, USALovelace Biomedical Research Institute, Albuquerque, NM 87108, USAInstitute of Electronics, Bulgarian Academy of Sciences, Tsarigradsko Chaussee Blvd. 72, 1784 Sofia, BulgariaPhysics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, GermanyOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham B4 7ET, UKOver sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm<sup>2</sup> firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.https://www.mdpi.com/1422-0067/24/18/13696glioblastomaphototherapyquantum-dot 1267 nm laserNIR laser oxidative cell damaginglymphatic system |
| spellingShingle | Oxana Semyachkina-Glushkovskaya Sergey Sokolovski Ivan Fedosov Alexander Shirokov Nikita Navolokin Alla Bucharskaya Inna Blokhina Andrey Terskov Alexander Dubrovski Valeria Telnova Anna Tzven Maria Tzoy Arina Evsukova Daria Zhlatogosrkaya Viktoria Adushkina Alexander Dmitrenko Maria Manzhaeva Valeria Krupnova Alessio Noghero Denis Bragin Olga Bragina Ekaterina Borisova Jürgen Kurths Edik Rafailov Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain International Journal of Molecular Sciences glioblastoma phototherapy quantum-dot 1267 nm laser NIR laser oxidative cell damaging lymphatic system |
| title | Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain |
| title_full | Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain |
| title_fullStr | Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain |
| title_full_unstemmed | Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain |
| title_short | Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain |
| title_sort | transcranial photosensitizer free laser treatment of glioblastoma in rat brain |
| topic | glioblastoma phototherapy quantum-dot 1267 nm laser NIR laser oxidative cell damaging lymphatic system |
| url | https://www.mdpi.com/1422-0067/24/18/13696 |
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