Activity disruption causes degeneration of entorhinal neurons in a mouse model of Alzheimer’s circuit dysfunction
Neurodegenerative diseases are characterized by selective vulnerability of distinct cell populations; however, the cause for this specificity remains elusive. Here, we show that entorhinal cortex layer 2 (EC2) neurons are unusually vulnerable to prolonged neuronal inactivity compared with neighborin...
Main Authors: | Rong Zhao, Stacy D Grunke, Caleb A Wood, Gabriella A Perez, Melissa Comstock, Ming-Hua Li, Anand K Singh, Kyung-Won Park, Joanna L Jankowsky |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-12-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/83813 |
Similar Items
-
Use it or lose it
by: Ohad Rechnitz, et al.
Published: (2023-01-01) -
Entorhinal cortex volume in antipsychotic-naïve schizophrenia
by: Sam P Jose, et al.
Published: (2012-01-01) -
Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
by: Joeri BG van Wijngaarden, et al.
Published: (2020-11-01) -
Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex
by: Virginie Bottero, et al.
Published: (2021-04-01) -
Landscape of immune infiltration in entorhinal cortex of patients with Alzheimerʼs disease
by: Hui Zhang, et al.
Published: (2022-09-01)