Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp.
Essential oils (EOs) have been shown to have a diversity of beneficial human health effects. <i>Clausena</i> is a large and highly diverse genus of plants with medicinal and cosmetic significance. The aim of this study was to analyze the composition of <i>Clausena lansium</i>...
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MDPI AG
2019-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/7/1394 |
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| author | Xiaowen He Lantong Zhang Jinping Chen Jinlei Sui Guohui Yi Jinyan Wu Yinzheng Ma |
| author_facet | Xiaowen He Lantong Zhang Jinping Chen Jinlei Sui Guohui Yi Jinyan Wu Yinzheng Ma |
| author_sort | Xiaowen He |
| collection | DOAJ |
| description | Essential oils (EOs) have been shown to have a diversity of beneficial human health effects. <i>Clausena</i> is a large and highly diverse genus of plants with medicinal and cosmetic significance. The aim of this study was to analyze the composition of <i>Clausena lansium</i> EOs and to investigate their potential antifungal effects. The chemical compositions of <i>Clausena lansium</i> EOs obtained by hydrodistillation were analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 101 compounds were identified among the diverse extracts of <i>C. lansium</i>. EOs of leaves and pericarps from different cultivars (Hainan local wampee and chicken heart wampee) collected in Hainan (China) were classified into four clusters based on their compositions. These clusters showed different antifungal activities against five <i>Candida</i> species (<i>C. albicans</i>, <i>C. tropicalis</i>, <i>C. glabrata</i>, <i>C. krusei</i> and <i>C. parapsilosis</i>) using the disc diffusion method. <i>Clausena lansium</i> EOs of pericarps displayed noteworthy antifungal activitives against all the tested <i>Candida</i> strains with inhibition zone diameters in the range of 11.1–23.1 mm. EOs of leaves showed relatively low antifungal activities with inhibition zone diameters in the range of 6.5–22.2 mm. The rank order of antifungal activities among the four EO clusters was as follows: Cluster IV> Cluster III > Cluster I ≥ Cluster II. These results represent the first report about the correlation between chemical composition of <i>C. lansium</i> EOs and antifungal activity. Higher contents of β-phellandrene, β-sesquiphellandrene and β-bisabolene in EOs of pericarps were likely responsible for the high antifungal activity of Cluster IV EOs. Taken together, our results demonstrate the chemical diversity of <i>Clausena lansium</i> EOs and their potential as novel antifungal agents for candidiasis caused by <i>Candida</i> spp. Furthermore, the obtained results showing a wide spectrum of antifungal activities provide scientific evidence for the traditional use of these plants. |
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| spelling | doaj.art-3fe1ef449106442faef43ebc7ff1b6ec2022-12-22T03:15:21ZengMDPI AGMolecules1420-30492019-04-01247139410.3390/molecules24071394molecules24071394Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp.Xiaowen He0Lantong Zhang1Jinping Chen2Jinlei Sui3Guohui Yi4Jinyan Wu5Yinzheng Ma6Public Research Laboratory, Hainan Medical University, Haikou 571199, Hainan, ChinaSchool of Pharmacy, Hebei Medical University, Shijiazhuang 050017, Hebei, ChinaPublic Research Laboratory, Hainan Medical University, Haikou 571199, Hainan, ChinaPublic Research Laboratory, Hainan Medical University, Haikou 571199, Hainan, ChinaPublic Research Laboratory, Hainan Medical University, Haikou 571199, Hainan, ChinaPublic Research Laboratory, Hainan Medical University, Haikou 571199, Hainan, ChinaSchool of Public Health, Hainan Medical University, Haikou 571199, Hainan, ChinaEssential oils (EOs) have been shown to have a diversity of beneficial human health effects. <i>Clausena</i> is a large and highly diverse genus of plants with medicinal and cosmetic significance. The aim of this study was to analyze the composition of <i>Clausena lansium</i> EOs and to investigate their potential antifungal effects. The chemical compositions of <i>Clausena lansium</i> EOs obtained by hydrodistillation were analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 101 compounds were identified among the diverse extracts of <i>C. lansium</i>. EOs of leaves and pericarps from different cultivars (Hainan local wampee and chicken heart wampee) collected in Hainan (China) were classified into four clusters based on their compositions. These clusters showed different antifungal activities against five <i>Candida</i> species (<i>C. albicans</i>, <i>C. tropicalis</i>, <i>C. glabrata</i>, <i>C. krusei</i> and <i>C. parapsilosis</i>) using the disc diffusion method. <i>Clausena lansium</i> EOs of pericarps displayed noteworthy antifungal activitives against all the tested <i>Candida</i> strains with inhibition zone diameters in the range of 11.1–23.1 mm. EOs of leaves showed relatively low antifungal activities with inhibition zone diameters in the range of 6.5–22.2 mm. The rank order of antifungal activities among the four EO clusters was as follows: Cluster IV> Cluster III > Cluster I ≥ Cluster II. These results represent the first report about the correlation between chemical composition of <i>C. lansium</i> EOs and antifungal activity. Higher contents of β-phellandrene, β-sesquiphellandrene and β-bisabolene in EOs of pericarps were likely responsible for the high antifungal activity of Cluster IV EOs. Taken together, our results demonstrate the chemical diversity of <i>Clausena lansium</i> EOs and their potential as novel antifungal agents for candidiasis caused by <i>Candida</i> spp. Furthermore, the obtained results showing a wide spectrum of antifungal activities provide scientific evidence for the traditional use of these plants.https://www.mdpi.com/1420-3049/24/7/1394correlation<i>Clausena lansium</i>essential oilantifungal activity<i>Candida</i> spp. |
| spellingShingle | Xiaowen He Lantong Zhang Jinping Chen Jinlei Sui Guohui Yi Jinyan Wu Yinzheng Ma Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. Molecules correlation <i>Clausena lansium</i> essential oil antifungal activity <i>Candida</i> spp. |
| title | Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. |
| title_full | Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. |
| title_fullStr | Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. |
| title_full_unstemmed | Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. |
| title_short | Correlation between Chemical Composition and Antifungal Activity of <i>Clausena lansium</i> Essential Oil against <i>Candida</i> spp. |
| title_sort | correlation between chemical composition and antifungal activity of i clausena lansium i essential oil against i candida i spp |
| topic | correlation <i>Clausena lansium</i> essential oil antifungal activity <i>Candida</i> spp. |
| url | https://www.mdpi.com/1420-3049/24/7/1394 |
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