Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical d...
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.609562/full |
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| author | Shangzhu Zhang Yanhong Wang Linyi Peng Jinmei Su Xiaofeng Zeng Mengtao Li Zhenbiao Wu Jian Xu Min Yang Lijun Wu Cheng Zhao Xinwang Duan Qin Li Jing Zhu Wenqiang Fan |
| author_facet | Shangzhu Zhang Yanhong Wang Linyi Peng Jinmei Su Xiaofeng Zeng Mengtao Li Zhenbiao Wu Jian Xu Min Yang Lijun Wu Cheng Zhao Xinwang Duan Qin Li Jing Zhu Wenqiang Fan |
| author_sort | Shangzhu Zhang |
| collection | DOAJ |
| description | Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence.Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence.Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis. |
| first_indexed | 2024-12-14T02:21:17Z |
| format | Article |
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| language | English |
| last_indexed | 2024-12-14T02:21:17Z |
| publishDate | 2020-12-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-3fe20bc5dd5648bcbf49e8796594afd92022-12-21T23:20:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-12-01710.3389/fmed.2020.609562609562Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 PatientsShangzhu Zhang0Yanhong Wang1Linyi Peng2Jinmei Su3Xiaofeng Zeng4Mengtao Li5Zhenbiao Wu6Jian Xu7Min Yang8Lijun Wu9Cheng Zhao10Xinwang Duan11Qin Li12Jing Zhu13Wenqiang Fan14Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Epidemiology and Bio-Statistics (YW), Peking Union Medical College, Institute of Basic Medical Sciences, China Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaKey Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Ministry of Science and Technology, Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Xi'an, ChinaDepartment of Rheumatology, Kunming Medical University First Affiliated Hospital, Kunming, ChinaDepartment of Rheumatology, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou, ChinaDepartment of Rheumatology, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, ChinaDepartment of Rheumatology, Guangxi Medical University First Affiliated Hospital, Nanning, ChinaDepartment of Rheumatology, Nanchang University Second Affiliated Hospital, Nanchang, ChinaDepartment of Rheumatology, First People's Hospital of Yunnan, Kunming, China0Department of Rheumatology, Sichuan Provincial People's Hospital, Chengdu, China1Department of Rheumatology, Xinxiang Central Hospital, Xinxiang, ChinaObjective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA database was performed. Demographic and clinical data were compared in terms of the HLA-B27 status. Univariate and multivariate analyses were performed to identify variables related to HLA-B27 presence.Results: We enrolled 4,131 patients in this study; of those, 36,95 (89.4%) were HLA-B27 positive. In the multivariate analysis, male gender (p < 0.001), younger age (p < 0.001), a disease duration of more than 3 years (p < 0.001), a family history of SpA (p < 0.001), uveitis (p < 0.001), ASDAS-CRP (p < 0.001), and biologic treatment (p < 0.001) were the main variables that were independently related to HLA-B27 presence, whereas a diagnosis delay time >36 months (p < 0.001) and psoriasis (p < 0.001) were independently related to HLA-B27 absence.Conclusion: In Chinese axial SpA patients, presence of HLA-B27 is associated with the male sex, younger age, longer disease duration, greater family aggregation, and higher frequency of uveitis; absence of HLA-B27 is associated with longer diagnosis delay time and higher frequency of psoriasis.https://www.frontiersin.org/articles/10.3389/fmed.2020.609562/fullHLA-B27family historyuveitispsoriasisaxial spondyloarthritis (axSpA) |
| spellingShingle | Shangzhu Zhang Yanhong Wang Linyi Peng Jinmei Su Xiaofeng Zeng Mengtao Li Zhenbiao Wu Jian Xu Min Yang Lijun Wu Cheng Zhao Xinwang Duan Qin Li Jing Zhu Wenqiang Fan Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients Frontiers in Medicine HLA-B27 family history uveitis psoriasis axial spondyloarthritis (axSpA) |
| title | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients |
| title_full | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients |
| title_fullStr | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients |
| title_full_unstemmed | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients |
| title_short | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients |
| title_sort | comparison of clinical features in hla b27 positive and negative patients with axial spondyloarthritis results from a cohort of 4 131 patients |
| topic | HLA-B27 family history uveitis psoriasis axial spondyloarthritis (axSpA) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.609562/full |
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