CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION

CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION

The patient with the verified diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics, calcium channel blocker. After one year of adding endothelin receptor antagonist bosentan there was noticed the negative dynamic with right heart chamber...

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Bibliographic Details
Main Authors: V. V. Bystrov, O. A. Arkhipova, T. V. Martynyuk, M. A. Saidova, O. V. Stukalova, N. M. Danilov, T. A. Sakhnova, I. Ye. Chazova
Format: Article
Language:Russian
Published: InterMedservice 2014-12-01
Series:Евразийский Кардиологический Журнал
Subjects:
идиопатическая лёгочная гипертензия
комбинированная лаг-специфическая терапия
антагонист рецепторов эндотелина
эндотелин-1
ингибитор фосфодиэстеразы типа 5
бозентан
силденафил
phosphodiesterase type 5 inhibitor
sildenafil
idiopathic pulmonary hypertension
endothelin receptor antagonists
bosentan
Online Access:https://www.heartj.asia/jour/article/view/5611
Description
Summary:The patient with the verified diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics, calcium channel blocker. After one year of adding endothelin receptor antagonist bosentan there was noticed the negative dynamic with right heart chambers dilation, appearing of heart failure signs. By 11 months of the combined pathogenetic therapy with bosentan and phosphodiesterase type 5 inhibitor sildenafil there was achieved the significant improvement of the functional and hemodynamic status. This positive dynamics remained within the next 3 years of observation.
ISSN:2225-1685
2305-0748

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