SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/22/5636 |
| _version_ | 1797465699496493056 |
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| author | Wenmin Yang Te Zhang Xuming Song Gaochao Dong Lin Xu Feng Jiang |
| author_facet | Wenmin Yang Te Zhang Xuming Song Gaochao Dong Lin Xu Feng Jiang |
| author_sort | Wenmin Yang |
| collection | DOAJ |
| description | Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances. In this review, based on the different positions of SNPs and their modes of action, we discuss the mechanisms underlying how SNPs regulate the expression of target genes to consequently affect tumorigenesis and the development of cancer. |
| first_indexed | 2024-03-09T18:26:12Z |
| format | Article |
| id | doaj.art-3fe60370e67045818f50b8b7d399fed2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T18:26:12Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3fe60370e67045818f50b8b7d399fed22023-11-24T07:54:19ZengMDPI AGCancers2072-66942022-11-011422563610.3390/cancers14225636SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWASWenmin Yang0Te Zhang1Xuming Song2Gaochao Dong3Lin Xu4Feng Jiang5Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaDepartment of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaDepartment of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaDepartment of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaDepartment of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaDepartment of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing 210009, ChinaCancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances. In this review, based on the different positions of SNPs and their modes of action, we discuss the mechanisms underlying how SNPs regulate the expression of target genes to consequently affect tumorigenesis and the development of cancer.https://www.mdpi.com/2072-6694/14/22/5636genome-wide association analysissingle nucleotide polymorphismcancermolecular and biological mechanism |
| spellingShingle | Wenmin Yang Te Zhang Xuming Song Gaochao Dong Lin Xu Feng Jiang SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS Cancers genome-wide association analysis single nucleotide polymorphism cancer molecular and biological mechanism |
| title | SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS |
| title_full | SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS |
| title_fullStr | SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS |
| title_full_unstemmed | SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS |
| title_short | SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS |
| title_sort | snp target genes interaction perturbing the cancer risk in the post gwas |
| topic | genome-wide association analysis single nucleotide polymorphism cancer molecular and biological mechanism |
| url | https://www.mdpi.com/2072-6694/14/22/5636 |
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