Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia
Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3215 |
| _version_ | 1797620591536111616 |
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| author | Shih-Chia Yeh Faith J. F. Cheong Yvonne Tay |
| author_facet | Shih-Chia Yeh Faith J. F. Cheong Yvonne Tay |
| author_sort | Shih-Chia Yeh |
| collection | DOAJ |
| description | Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is transcribed into non-coding RNAs (ncRNAs). This paradigm shift has led to an explosion of research interest in different classes of non-coding RNAs, such as circular RNAs (circRNAs) as well as non-coding untranslated regions (UTRs) of protein-coding messenger RNAs. The critical roles of circRNAs and UTRs in AML pathogenesis have become increasingly apparent. In this review, we discuss the cellular mechanisms of circRNAs and summarize recent studies that reveal their biological roles in AML. Furthermore, we also review the contribution of 3′UTRs to disease progression. Finally, we discuss the potential of circRNAs and 3′UTRs as new biomarkers for disease stratification and/or the prediction of treatment response and targets for the development of RNA-directed therapeutic applications. |
| first_indexed | 2024-03-11T08:43:47Z |
| format | Article |
| id | doaj.art-3fe67dfac8f74c3c8ecb093cdb34802b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:43:47Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3fe67dfac8f74c3c8ecb093cdb34802b2023-11-16T20:56:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244321510.3390/ijms24043215Circular RNAs and Untranslated Regions in Acute Myeloid LeukemiaShih-Chia Yeh0Faith J. F. Cheong1Yvonne Tay2Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeBefore the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is transcribed into non-coding RNAs (ncRNAs). This paradigm shift has led to an explosion of research interest in different classes of non-coding RNAs, such as circular RNAs (circRNAs) as well as non-coding untranslated regions (UTRs) of protein-coding messenger RNAs. The critical roles of circRNAs and UTRs in AML pathogenesis have become increasingly apparent. In this review, we discuss the cellular mechanisms of circRNAs and summarize recent studies that reveal their biological roles in AML. Furthermore, we also review the contribution of 3′UTRs to disease progression. Finally, we discuss the potential of circRNAs and 3′UTRs as new biomarkers for disease stratification and/or the prediction of treatment response and targets for the development of RNA-directed therapeutic applications.https://www.mdpi.com/1422-0067/24/4/3215circular RNA3′untranslated regionalternative polyadenylation3′UTR splicingsingle nucleotide polymorphism |
| spellingShingle | Shih-Chia Yeh Faith J. F. Cheong Yvonne Tay Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia International Journal of Molecular Sciences circular RNA 3′untranslated region alternative polyadenylation 3′UTR splicing single nucleotide polymorphism |
| title | Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia |
| title_full | Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia |
| title_fullStr | Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia |
| title_full_unstemmed | Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia |
| title_short | Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia |
| title_sort | circular rnas and untranslated regions in acute myeloid leukemia |
| topic | circular RNA 3′untranslated region alternative polyadenylation 3′UTR splicing single nucleotide polymorphism |
| url | https://www.mdpi.com/1422-0067/24/4/3215 |
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