Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial
BACKGROUND: Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during stress, depressive symptoms) that may cause deleterious effects on quality of life, and may be positively influenced by recombinant human growth hormone (rh-GH) ther...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
1999-06-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000200003&tlng=en |
| _version_ | 1798015240904900608 |
|---|---|
| author | CLÁUDIO DE NOVAES SOARES NINA ROSA MUSOLINO MALEBRANCHE CUNHA NETO MARIA ADELAIDE CAIRES MARIA CRISTINA ROSENTHAL CANDIDA PIRES CAMARGO MARCELLO D. BRONSTEIN |
| author_facet | CLÁUDIO DE NOVAES SOARES NINA ROSA MUSOLINO MALEBRANCHE CUNHA NETO MARIA ADELAIDE CAIRES MARIA CRISTINA ROSENTHAL CANDIDA PIRES CAMARGO MARCELLO D. BRONSTEIN |
| author_sort | CLÁUDIO DE NOVAES SOARES |
| collection | DOAJ |
| description | BACKGROUND: Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during stress, depressive symptoms) that may cause deleterious effects on quality of life, and may be positively influenced by recombinant human growth hormone (rh-GH) therapy. AIM: To evaluate the impact of a clinical intervention with rh-GH therapy on GH - deficient adults. METHOD: The physical, psychiatric and neuropsychological status of 9 GH-deficient adults was determined before and after the administration of rh-GH (0.250 IU/Kg/week) in a double blind placebo-controlled trial for six months. Patients then received rh-GH for a further period of 6 months and their status was re-evaluated. RESULTS: Rh-GH was significant better than placebo at 6th month (p<0.05), producing increased serum Insulin like growth factor-I (IGF-1) levels, reduced body mass index (BMI) and body fat, increased lean body mass and water, reduced waist/hip ratio and increased energy expenditure. The rh-GH therapy was also significantly better than placebo on depressive features as measured by the Hamilton Depression Scale (17-items) (p= 0.0431) and the Beck Depression Inventory (p= 0.0431). Neuropsychological evaluations showed significant improvements in measures of Attention: Digit Backward (p= 0.035),Verbal Fluency (FAS) (p= 0.02) and Cognitive Efficiency (WAIS-R tests): Vocabulary (p= 0.027) , Picture Arrangements (p= 0.017), and Comprehension (p= 0.01) following rh-GH therapy. CONCLUSION: The clinical, psychiatric, and neuropsychological impairments of untreated GH-deficient adults can be decreased by rh-GH therapy. |
| first_indexed | 2024-04-11T15:30:14Z |
| format | Article |
| id | doaj.art-3fe6d370e0514aec83ddf224bae3f094 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-11T15:30:14Z |
| publishDate | 1999-06-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3fe6d370e0514aec83ddf224bae3f0942022-12-22T04:16:09ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271999-06-01572A18218910.1590/S0004-282X1999000200003Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trialCLÁUDIO DE NOVAES SOARES0NINA ROSA MUSOLINO1MALEBRANCHE CUNHA NETO2MARIA ADELAIDE CAIRES3MARIA CRISTINA ROSENTHAL4CANDIDA PIRES CAMARGO5MARCELLO D. BRONSTEIN6Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloBACKGROUND: Untreated GH-deficient adults have a diversity of dysfunctions (e.g. reduced muscle strength, emotional instability during stress, depressive symptoms) that may cause deleterious effects on quality of life, and may be positively influenced by recombinant human growth hormone (rh-GH) therapy. AIM: To evaluate the impact of a clinical intervention with rh-GH therapy on GH - deficient adults. METHOD: The physical, psychiatric and neuropsychological status of 9 GH-deficient adults was determined before and after the administration of rh-GH (0.250 IU/Kg/week) in a double blind placebo-controlled trial for six months. Patients then received rh-GH for a further period of 6 months and their status was re-evaluated. RESULTS: Rh-GH was significant better than placebo at 6th month (p<0.05), producing increased serum Insulin like growth factor-I (IGF-1) levels, reduced body mass index (BMI) and body fat, increased lean body mass and water, reduced waist/hip ratio and increased energy expenditure. The rh-GH therapy was also significantly better than placebo on depressive features as measured by the Hamilton Depression Scale (17-items) (p= 0.0431) and the Beck Depression Inventory (p= 0.0431). Neuropsychological evaluations showed significant improvements in measures of Attention: Digit Backward (p= 0.035),Verbal Fluency (FAS) (p= 0.02) and Cognitive Efficiency (WAIS-R tests): Vocabulary (p= 0.027) , Picture Arrangements (p= 0.017), and Comprehension (p= 0.01) following rh-GH therapy. CONCLUSION: The clinical, psychiatric, and neuropsychological impairments of untreated GH-deficient adults can be decreased by rh-GH therapy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000200003&tlng=engrowth-hormone deficiencyadulttreatmentpsychiatrydepression |
| spellingShingle | CLÁUDIO DE NOVAES SOARES NINA ROSA MUSOLINO MALEBRANCHE CUNHA NETO MARIA ADELAIDE CAIRES MARIA CRISTINA ROSENTHAL CANDIDA PIRES CAMARGO MARCELLO D. BRONSTEIN Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial Arquivos de Neuro-Psiquiatria growth-hormone deficiency adult treatment psychiatry depression |
| title | Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial |
| title_full | Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial |
| title_fullStr | Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial |
| title_full_unstemmed | Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial |
| title_short | Impact of recombinant human growth hormone (rh-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults: a placebo - controlled trial |
| title_sort | impact of recombinant human growth hormone rh gh treatment on psychiatric neuropsychological and clinical profiles of gh deficient adults a placebo controlled trial |
| topic | growth-hormone deficiency adult treatment psychiatry depression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000200003&tlng=en |
| work_keys_str_mv | AT claudiodenovaessoares impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT ninarosamusolino impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT malebranchecunhaneto impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT mariaadelaidecaires impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT mariacristinarosenthal impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT candidapirescamargo impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial AT marcellodbronstein impactofrecombinanthumangrowthhormonerhghtreatmentonpsychiatricneuropsychologicalandclinicalprofilesofghdeficientadultsaplacebocontrolledtrial |