Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor
Opsins are G protein-coupled receptors which are activated by light-triggered retinal 11-cis-to-all-trans photoisomerization. Here, the authors report a vertebrate non-visual opsin (Opn5L1) that functions as a Gi-coupled retinal receptor, is deactivated by light and can thermally self-regenerate.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03603-3 |
| _version_ | 1818341867736006656 |
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| author | Keita Sato Takahiro Yamashita Hideyo Ohuchi Atsuko Takeuchi Hitoshi Gotoh Katsuhiko Ono Misao Mizuno Yasuhisa Mizutani Sayuri Tomonari Kazumi Sakai Yasushi Imamoto Akimori Wada Yoshinori Shichida |
| author_facet | Keita Sato Takahiro Yamashita Hideyo Ohuchi Atsuko Takeuchi Hitoshi Gotoh Katsuhiko Ono Misao Mizuno Yasuhisa Mizutani Sayuri Tomonari Kazumi Sakai Yasushi Imamoto Akimori Wada Yoshinori Shichida |
| author_sort | Keita Sato |
| collection | DOAJ |
| description | Opsins are G protein-coupled receptors which are activated by light-triggered retinal 11-cis-to-all-trans photoisomerization. Here, the authors report a vertebrate non-visual opsin (Opn5L1) that functions as a Gi-coupled retinal receptor, is deactivated by light and can thermally self-regenerate. |
| first_indexed | 2024-12-13T16:05:37Z |
| format | Article |
| id | doaj.art-3fe70ccf8c3742ffb0bddb9e1628427b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:05:37Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3fe70ccf8c3742ffb0bddb9e1628427b2022-12-21T23:39:03ZengNature PortfolioNature Communications2041-17232018-03-019111010.1038/s41467-018-03603-3Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptorKeita Sato0Takahiro Yamashita1Hideyo Ohuchi2Atsuko Takeuchi3Hitoshi Gotoh4Katsuhiko Ono5Misao Mizuno6Yasuhisa Mizutani7Sayuri Tomonari8Kazumi Sakai9Yasushi Imamoto10Akimori Wada11Yoshinori Shichida12Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Biophysics, Graduate School of Science, Kyoto UniversityDepartment of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesDivision of Analytical Laboratory, Kobe Pharmaceutical UniversityDepartment of Biology, Kyoto Prefectural University of MedicineDepartment of Biology, Kyoto Prefectural University of MedicineDepartment of Chemistry, Graduate School of Science, Osaka UniversityDepartment of Chemistry, Graduate School of Science, Osaka UniversityDivision of Chemical and Physical Analyses, Center for Technical Support, Institute of Technology and Science, Tokushima UniversityDepartment of Biophysics, Graduate School of Science, Kyoto UniversityDepartment of Biophysics, Graduate School of Science, Kyoto UniversityDepartment of Organic Chemistry for Life Science, Kobe Pharmaceutical UniversityDepartment of Biophysics, Graduate School of Science, Kyoto UniversityOpsins are G protein-coupled receptors which are activated by light-triggered retinal 11-cis-to-all-trans photoisomerization. Here, the authors report a vertebrate non-visual opsin (Opn5L1) that functions as a Gi-coupled retinal receptor, is deactivated by light and can thermally self-regenerate.https://doi.org/10.1038/s41467-018-03603-3 |
| spellingShingle | Keita Sato Takahiro Yamashita Hideyo Ohuchi Atsuko Takeuchi Hitoshi Gotoh Katsuhiko Ono Misao Mizuno Yasuhisa Mizutani Sayuri Tomonari Kazumi Sakai Yasushi Imamoto Akimori Wada Yoshinori Shichida Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor Nature Communications |
| title | Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor |
| title_full | Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor |
| title_fullStr | Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor |
| title_full_unstemmed | Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor |
| title_short | Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor |
| title_sort | opn5l1 is a retinal receptor that behaves as a reverse and self regenerating photoreceptor |
| url | https://doi.org/10.1038/s41467-018-03603-3 |
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