Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review
Pancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not...
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| author | Andrea Coppola Dario Grasso Federico Fontana Filippo Piacentino Roberto Minici Domenico Laganà Anna Maria Ierardi Gianpaolo Carrafiello Fabio D’Angelo Giulio Carcano Massimo Venturini |
| author_facet | Andrea Coppola Dario Grasso Federico Fontana Filippo Piacentino Roberto Minici Domenico Laganà Anna Maria Ierardi Gianpaolo Carrafiello Fabio D’Angelo Giulio Carcano Massimo Venturini |
| author_sort | Andrea Coppola |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not-expensive device that helps researchers in several ways. In this systematic review, we propose a summary of the applications of ultrasonography in a preclinical mouse model of PDAC. Eighty-eight studies met our inclusion criteria. The included studies could be divided into seven main topics: ultrasound in pancreatic cancer diagnosis and progression (n: 21); dynamic contrast-enhanced ultrasound (DCE-US) (n: 5); microbubble ultra-sound-mediated drug delivery; focused ultrasound (n: 23); sonodynamic therapy (SDT) (n: 7); harmonic motion elastography (HME) and shear wave elastography (SWE) (n: 6); ultrasound-guided procedures (n: 9). In six cases, the articles fit into two or more sections. In conclusion, ultrasound can be a really useful, eclectic, and ductile tool in different diagnostic areas, not only regarding diagnosis but also in therapy, pharmacological and interventional treatment, and follow-up. All these multiple possibilities of use certainly represent a good starting point for the effective and wide use of murine ultrasonography in the study and comprehensive evaluation of pancreatic cancer. |
| first_indexed | 2024-03-08T20:38:42Z |
| format | Article |
| id | doaj.art-3fe8cd71397148778d1f9742a180dc14 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:38:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3fe8cd71397148778d1f9742a180dc142023-12-22T14:17:24ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224767710.3390/jcm12247677Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic ReviewAndrea Coppola0Dario Grasso1Federico Fontana2Filippo Piacentino3Roberto Minici4Domenico Laganà5Anna Maria Ierardi6Gianpaolo Carrafiello7Fabio D’Angelo8Giulio Carcano9Massimo Venturini10Diagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, ItalyDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, ItalyDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, ItalyDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, ItalyRadiology Unit, Dulbecco University Hospital, 88100 Catanzaro, ItalyRadiology Unit, Dulbecco University Hospital, 88100 Catanzaro, ItalyRadiology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyRadiology Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Medicine and Surgery, Insubria University, 21100 Varese, ItalyDepartment of Medicine and Technological Innovation, Insubria University, 21100 Varese, ItalyDiagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, ItalyPancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not-expensive device that helps researchers in several ways. In this systematic review, we propose a summary of the applications of ultrasonography in a preclinical mouse model of PDAC. Eighty-eight studies met our inclusion criteria. The included studies could be divided into seven main topics: ultrasound in pancreatic cancer diagnosis and progression (n: 21); dynamic contrast-enhanced ultrasound (DCE-US) (n: 5); microbubble ultra-sound-mediated drug delivery; focused ultrasound (n: 23); sonodynamic therapy (SDT) (n: 7); harmonic motion elastography (HME) and shear wave elastography (SWE) (n: 6); ultrasound-guided procedures (n: 9). In six cases, the articles fit into two or more sections. In conclusion, ultrasound can be a really useful, eclectic, and ductile tool in different diagnostic areas, not only regarding diagnosis but also in therapy, pharmacological and interventional treatment, and follow-up. All these multiple possibilities of use certainly represent a good starting point for the effective and wide use of murine ultrasonography in the study and comprehensive evaluation of pancreatic cancer.https://www.mdpi.com/2077-0383/12/24/7677pancreatic cancerexperimental animal modelsmousediagnostic imagingultrasound imagingultrasonic therapy |
| spellingShingle | Andrea Coppola Dario Grasso Federico Fontana Filippo Piacentino Roberto Minici Domenico Laganà Anna Maria Ierardi Gianpaolo Carrafiello Fabio D’Angelo Giulio Carcano Massimo Venturini Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review Journal of Clinical Medicine pancreatic cancer experimental animal models mouse diagnostic imaging ultrasound imaging ultrasonic therapy |
| title | Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_full | Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_fullStr | Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_full_unstemmed | Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_short | Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review |
| title_sort | innovative experimental ultrasound and us related techniques using the murine model in pancreatic ductal adenocarcinoma a systematic review |
| topic | pancreatic cancer experimental animal models mouse diagnostic imaging ultrasound imaging ultrasonic therapy |
| url | https://www.mdpi.com/2077-0383/12/24/7677 |
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