Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study
Background: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on differe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487523000016 |
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| author | Raheleh Karimi Ehsan Zarepur Alireza Khosravi Noushin Mohammadifard Fereidoon Nouhi Hasan Alikhasi Shima Nasirian Masoumeh Sadeghi Hamidreza Roohafza Seyed Ali Moezi Bady Parisa janjani Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Mahboobeh Gholipour Mostafa dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza madadi Javad Kojuri Marjan Mansourian Nizal Sarrafzadegan |
| author_facet | Raheleh Karimi Ehsan Zarepur Alireza Khosravi Noushin Mohammadifard Fereidoon Nouhi Hasan Alikhasi Shima Nasirian Masoumeh Sadeghi Hamidreza Roohafza Seyed Ali Moezi Bady Parisa janjani Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Mahboobeh Gholipour Mostafa dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza madadi Javad Kojuri Marjan Mansourian Nizal Sarrafzadegan |
| author_sort | Raheleh Karimi |
| collection | DOAJ |
| description | Background: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on different ethnicities. Methods and results: Our study includes 1917 men and women with confirmed diagnosis of premature CAD. Logistic regression model was used to evaluate the high LDL cholesterol control in the groups and the OR with 95% confidence interval (CI) was reported as the effect size. After adjustment for confounders, the odds of controlling LDL in women taking Lovastatin, Rosuvastatin, and Simvastatin were 0.27 (0.03, 0.45) lower in comparison with men. Also, in participant who took 3 types of statins, the odds of controlling LDL were significantly different between Lor and Arab compared with Fars ethnicity. After adjustment to all confounders (full model), the odds of controlling LDL were lower for Gilak in Lovastatin, Rosuvastatin, and Simvastatin by 0.64 (0.47, 0.75); 0.61 (0.43, 0.73); 0.63 (0.46, 0.74) respectively and higher for Arab in Lovastatin, Rosuvastatin, and Simvastatin by 4.63 (18.28, 0.73); 4.67 (17.47, 0.74); 4.55 (17.03, 0.71) respectively compared to Fars. Conclusions: Major differences in different gender and ethnicities may have had led to disparities in statin use and LDL control. Awareness of the statins impact on high LDL cholesterol based on different ethnicities can help health decision-makers to close the observed gaps in statin use and control LDL to prevent CAD problems. |
| first_indexed | 2024-04-10T08:48:55Z |
| format | Article |
| id | doaj.art-3fea9b180a9740d6a2e399b17e00f0cc |
| institution | Directory Open Access Journal |
| issn | 2772-4875 |
| language | English |
| last_indexed | 2024-04-10T08:48:55Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj.art-3fea9b180a9740d6a2e399b17e00f0cc2023-02-22T04:32:39ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752023-03-0116200168Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD studyRaheleh Karimi0Ehsan Zarepur1Alireza Khosravi2Noushin Mohammadifard3Fereidoon Nouhi4Hasan Alikhasi5Shima Nasirian6Masoumeh Sadeghi7Hamidreza Roohafza8Seyed Ali Moezi Bady9 Parisa janjani10Kamal Solati11Masoud Lotfizadeh12Samad Ghaffari13Elmira Javanmardi14Mahboobeh Gholipour15 Mostafa dehghani16Mostafa Cheraghi17Ahmadreza Assareh18Habib Haybar19Seyedeh Mahdieh Namayandeh20 Reza madadi21Javad Kojuri22Marjan Mansourian23Nizal Sarrafzadegan24Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran; Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Cardiology, Medicine School, Isfahan University of Medical Sciences, Isfahan, IranHypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; The Iranian Network of Cardiovascular Research (INCVR), IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; The Iranian Network of Cardiovascular Research (INCVR), IranHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranPediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran; Clinical Research Development Unit, Imam Reza Hospital, Birjand University of Medical Sciences, Birjand, IranCardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, IranSocial determinants of Health Research Center, Shahrekord University of Medical Sciences, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; The Iranian Network of Cardiovascular Research (INCVR), IranDepartment of Cardiovascular Medicine, Heart Center, Maraghe University of Medical Sciences, Amiralmomenin Hospital, IranDepartment of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Science, Khorramabad, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Science, Khorramabad, IranAtherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; The Iranian Network of Cardiovascular Research (INCVR), IranAtherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranYazd Cardiovascular Research Center, Shahid Sadooghi University of Medical Science, IranAssociate Perofessor of Cardiology, Zanjan University of Medical Sciences, IranClinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; The Iranian Network of Cardiovascular Research (INCVR), IranPediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding author. Shahid Rahmani Alley, Moshtagh 3rd St, Isfahan Cardiovascular Research Institute, 8166173414, Isfahan, Iran.Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; The Iranian Network of Cardiovascular Research (INCVR), Iran; Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, CanadaBackground: Statins use is the most important treatment for high LDL cholesterol in patients with premature coronary artery disease (CAD). Previous reports have shown racial and gender differences in statin use in the general population, but this wasn't studied in premature CAD based on different ethnicities. Methods and results: Our study includes 1917 men and women with confirmed diagnosis of premature CAD. Logistic regression model was used to evaluate the high LDL cholesterol control in the groups and the OR with 95% confidence interval (CI) was reported as the effect size. After adjustment for confounders, the odds of controlling LDL in women taking Lovastatin, Rosuvastatin, and Simvastatin were 0.27 (0.03, 0.45) lower in comparison with men. Also, in participant who took 3 types of statins, the odds of controlling LDL were significantly different between Lor and Arab compared with Fars ethnicity. After adjustment to all confounders (full model), the odds of controlling LDL were lower for Gilak in Lovastatin, Rosuvastatin, and Simvastatin by 0.64 (0.47, 0.75); 0.61 (0.43, 0.73); 0.63 (0.46, 0.74) respectively and higher for Arab in Lovastatin, Rosuvastatin, and Simvastatin by 4.63 (18.28, 0.73); 4.67 (17.47, 0.74); 4.55 (17.03, 0.71) respectively compared to Fars. Conclusions: Major differences in different gender and ethnicities may have had led to disparities in statin use and LDL control. Awareness of the statins impact on high LDL cholesterol based on different ethnicities can help health decision-makers to close the observed gaps in statin use and control LDL to prevent CAD problems.http://www.sciencedirect.com/science/article/pii/S2772487523000016Coronary artery diseaseEthnicityRisk factorsIran |
| spellingShingle | Raheleh Karimi Ehsan Zarepur Alireza Khosravi Noushin Mohammadifard Fereidoon Nouhi Hasan Alikhasi Shima Nasirian Masoumeh Sadeghi Hamidreza Roohafza Seyed Ali Moezi Bady Parisa janjani Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Mahboobeh Gholipour Mostafa dehghani Mostafa Cheraghi Ahmadreza Assareh Habib Haybar Seyedeh Mahdieh Namayandeh Reza madadi Javad Kojuri Marjan Mansourian Nizal Sarrafzadegan Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study International Journal of Cardiology. Cardiovascular Risk and Prevention Coronary artery disease Ethnicity Risk factors Iran |
| title | Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study |
| title_full | Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study |
| title_fullStr | Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study |
| title_full_unstemmed | Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study |
| title_short | Ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease-results of I-PAD study |
| title_sort | ethnicity based differences in statin use and hypercholesterolemia control among patients with premature coronary artery disease results of i pad study |
| topic | Coronary artery disease Ethnicity Risk factors Iran |
| url | http://www.sciencedirect.com/science/article/pii/S2772487523000016 |
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