Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study
Purpose: The use of platelet-rich plasma (PRP) for the treatment of nonhealing ulcers is a relatively new technique. Although it seems to result in a satisfying level of healing and low complication rates, data regarding its effectiveness remain sparse. This study aims to evaluate the potential ther...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medrang
2019-03-01
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| Series: | Vascular Specialist International |
| Subjects: | |
| Online Access: | http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.22 |
| _version_ | 1818833431753129984 |
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| author | Maria Tsachiridi George Galyfos Alexandros Andreou Argiri Sianou Fragiska Sigala George Zografos Konstantinos Filis |
| author_facet | Maria Tsachiridi George Galyfos Alexandros Andreou Argiri Sianou Fragiska Sigala George Zografos Konstantinos Filis |
| author_sort | Maria Tsachiridi |
| collection | DOAJ |
| description | Purpose: The use of platelet-rich plasma (PRP) for the treatment of nonhealing ulcers is a relatively new technique. Although it seems to result in a satisfying level of healing and low complication rates, data regarding its effectiveness remain sparse. This study aims to evaluate the potential therapeutic effects of PRP on chronic nonhealing ulcers.
Materials and Methods: This was a prospectively designed study comparing outcomes between patients treated with PRP (Group A, n=15) and patients treated conventionally (Group B, n=12) for different types of nonhealing ulcers. In Group A, PRP was produced from the patients’ own peripheral blood samples and was applied on the ulcer once every week. In Group B, patients were treated conventionally, without applying PRP. The total treatment period was 5 weeks.
Results: Both groups were similar regarding age, sex, comorbidities, and time of treatment. In Group A, patients showed a nonsignificant reduction of 4.5 mm2 in ulcer area (P=0.190) and a reduction of more than 1 mm in depth (P=0.0006), while Group B showed an increase of 108±80.5 mm2 in ulcer area after 5 weeks (P=0.016). The healing rate (HR) in Group A was stable and positive throughout the treatment period, while HR in Group B was initially negative but became positive after the 3rd week.
Conclusion: PRP application once a week promotes the healing of chronic ulcers. It improves the ulcer’s depth and HR, although its effect on ulcer area seems to be nonsignificant. However, larger comparative series are still needed to confirm these findings. |
| first_indexed | 2024-12-19T02:18:49Z |
| format | Article |
| id | doaj.art-3feaf1c3e9744b769f16c51789edbebb |
| institution | Directory Open Access Journal |
| issn | 2288-7970 |
| language | English |
| last_indexed | 2024-12-19T02:18:49Z |
| publishDate | 2019-03-01 |
| publisher | Medrang |
| record_format | Article |
| series | Vascular Specialist International |
| spelling | doaj.art-3feaf1c3e9744b769f16c51789edbebb2022-12-21T20:40:19ZengMedrangVascular Specialist International2288-79702019-03-01351222710.5758/vsi.2019.35.1.22vsi.2019.35.1.22Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative StudyMaria Tsachiridi0George Galyfos1Alexandros Andreou2Argiri Sianou3Fragiska Sigala4George Zografos5Konstantinos Filis6First Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, GreeceFirst Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, GreeceDepartment of General Surgery, York Hospital, York Teaching Hospital NHS Trust, York, United KingdomDepartment of Microbiology, Areteion University Hospital, Athens, GreeceFirst Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, GreeceFirst Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, GreeceFirst Department of Propedeutic Surgery, Hippocration General Hospital, National Kapodistrian University of Athens, Athens, GreecePurpose: The use of platelet-rich plasma (PRP) for the treatment of nonhealing ulcers is a relatively new technique. Although it seems to result in a satisfying level of healing and low complication rates, data regarding its effectiveness remain sparse. This study aims to evaluate the potential therapeutic effects of PRP on chronic nonhealing ulcers. Materials and Methods: This was a prospectively designed study comparing outcomes between patients treated with PRP (Group A, n=15) and patients treated conventionally (Group B, n=12) for different types of nonhealing ulcers. In Group A, PRP was produced from the patients’ own peripheral blood samples and was applied on the ulcer once every week. In Group B, patients were treated conventionally, without applying PRP. The total treatment period was 5 weeks. Results: Both groups were similar regarding age, sex, comorbidities, and time of treatment. In Group A, patients showed a nonsignificant reduction of 4.5 mm2 in ulcer area (P=0.190) and a reduction of more than 1 mm in depth (P=0.0006), while Group B showed an increase of 108±80.5 mm2 in ulcer area after 5 weeks (P=0.016). The healing rate (HR) in Group A was stable and positive throughout the treatment period, while HR in Group B was initially negative but became positive after the 3rd week. Conclusion: PRP application once a week promotes the healing of chronic ulcers. It improves the ulcer’s depth and HR, although its effect on ulcer area seems to be nonsignificant. However, larger comparative series are still needed to confirm these findings.http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.22Platelet-rich plasmaUlcerRegeneration |
| spellingShingle | Maria Tsachiridi George Galyfos Alexandros Andreou Argiri Sianou Fragiska Sigala George Zografos Konstantinos Filis Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study Vascular Specialist International Platelet-rich plasma Ulcer Regeneration |
| title | Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study |
| title_full | Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study |
| title_fullStr | Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study |
| title_full_unstemmed | Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study |
| title_short | Autologous Platelet-Rich Plasma for Nonhealing Ulcers: A Comparative Study |
| title_sort | autologous platelet rich plasma for nonhealing ulcers a comparative study |
| topic | Platelet-rich plasma Ulcer Regeneration |
| url | http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.22 |
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