The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface
The maternal-fetal interface is defined as the interface between maternal tissue and sections of the fetus in close contact. RNA methylation modifications are the most frequent kind of RNA alterations. It is effective throughout both normal and pathological implantation and placentation during pregn...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1205408/full |
| _version_ | 1827855528107180032 |
|---|---|
| author | Shengyu Wu Shengyu Wu Han Xie Yao Su Yao Su Xinrui Jia Xinrui Jia Yabing Mi Yabing Mi Yuanhui Jia Hao Ying |
| author_facet | Shengyu Wu Shengyu Wu Han Xie Yao Su Yao Su Xinrui Jia Xinrui Jia Yabing Mi Yabing Mi Yuanhui Jia Hao Ying |
| author_sort | Shengyu Wu |
| collection | DOAJ |
| description | The maternal-fetal interface is defined as the interface between maternal tissue and sections of the fetus in close contact. RNA methylation modifications are the most frequent kind of RNA alterations. It is effective throughout both normal and pathological implantation and placentation during pregnancy. By influencing early embryo development, embryo implantation, endometrium receptivity, immune microenvironment, as well as some implantation and placentation-related disorders like miscarriage and preeclampsia, it is essential for the establishment of the maternal-fetal interface. Our review focuses on the role of dynamic RNA methylation at the maternal-fetal interface, which has received little attention thus far. It has given the mechanistic underpinnings for both normal and abnormal implantation and placentation and could eventually provide an entirely novel approach to treating related complications. |
| first_indexed | 2024-03-12T11:51:23Z |
| format | Article |
| id | doaj.art-3fee77f67ba4435bb958722e425eb80e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T11:51:23Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3fee77f67ba4435bb958722e425eb80e2023-08-31T06:27:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12054081205408The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interfaceShengyu Wu0Shengyu Wu1Han Xie2Yao Su3Yao Su4Xinrui Jia5Xinrui Jia6Yabing Mi7Yabing Mi8Yuanhui Jia9Hao Ying10Department of Clinical Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaClinical and Translational Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, ChinaThe maternal-fetal interface is defined as the interface between maternal tissue and sections of the fetus in close contact. RNA methylation modifications are the most frequent kind of RNA alterations. It is effective throughout both normal and pathological implantation and placentation during pregnancy. By influencing early embryo development, embryo implantation, endometrium receptivity, immune microenvironment, as well as some implantation and placentation-related disorders like miscarriage and preeclampsia, it is essential for the establishment of the maternal-fetal interface. Our review focuses on the role of dynamic RNA methylation at the maternal-fetal interface, which has received little attention thus far. It has given the mechanistic underpinnings for both normal and abnormal implantation and placentation and could eventually provide an entirely novel approach to treating related complications.https://www.frontiersin.org/articles/10.3389/fendo.2023.1205408/fullimplantationplacentationepigenetic modificationpost-transcriptional regulationRNA methylationmaternal-fetal interface |
| spellingShingle | Shengyu Wu Shengyu Wu Han Xie Yao Su Yao Su Xinrui Jia Xinrui Jia Yabing Mi Yabing Mi Yuanhui Jia Hao Ying The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface Frontiers in Endocrinology implantation placentation epigenetic modification post-transcriptional regulation RNA methylation maternal-fetal interface |
| title | The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface |
| title_full | The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface |
| title_fullStr | The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface |
| title_full_unstemmed | The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface |
| title_short | The landscape of implantation and placentation: deciphering the function of dynamic RNA methylation at the maternal-fetal interface |
| title_sort | landscape of implantation and placentation deciphering the function of dynamic rna methylation at the maternal fetal interface |
| topic | implantation placentation epigenetic modification post-transcriptional regulation RNA methylation maternal-fetal interface |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1205408/full |
| work_keys_str_mv | AT shengyuwu thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT shengyuwu thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT hanxie thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yaosu thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yaosu thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT xinruijia thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT xinruijia thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yabingmi thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yabingmi thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yuanhuijia thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT haoying thelandscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT shengyuwu landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT shengyuwu landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT hanxie landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yaosu landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yaosu landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT xinruijia landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT xinruijia landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yabingmi landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yabingmi landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT yuanhuijia landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface AT haoying landscapeofimplantationandplacentationdecipheringthefunctionofdynamicrnamethylationatthematernalfetalinterface |