DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis

DNA prime-protein boost based vaccination with a conserved region of leptospiral immunoglobulin-like A and B proteins enhances protection against leptospirosis

Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of theLeptospira genus. Vaccination with bacterins has severe limitations. Here, we evaluated the N-terminal region of the leptospiral immunoglobulin-like B protein (LigBrep) as a vaccine candidate against leptospirosis using immun...

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Bibliographic Details
Main Authors: Karine M Forster, Daiane D Hartwig, Thaís L Oliveira, Kátia L Bacelo, Rodrigo Schuch, Marta G Amaral, Odir A Dellagostin
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2015-12-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
leptospirosis
Leptospira
LigBrep
subunit vaccine
DNA vaccine
prime-boost
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000800989&lng=en&tlng=en

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