Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution.
Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P. vivax-like, was discovered in African great apes and is hypothesized to have given rise to P. vivax in humans. T...
| Glavni autori: | , , , , , , , , , , , , , , , |
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| Format: | Članak |
| Jezik: | English |
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Public Library of Science (PLoS)
2018-08-01
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| Serija: | PLoS Biology |
| Online pristup: | https://doi.org/10.1371/journal.pbio.2006035 |
| _version_ | 1831662058684284928 |
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| author | Aude Gilabert Thomas D Otto Gavin G Rutledge Blaise Franzon Benjamin Ollomo Céline Arnathau Patrick Durand Nancy D Moukodoum Alain-Prince Okouga Barthélémy Ngoubangoye Boris Makanga Larson Boundenga Christophe Paupy François Renaud Franck Prugnolle Virginie Rougeron |
| author_facet | Aude Gilabert Thomas D Otto Gavin G Rutledge Blaise Franzon Benjamin Ollomo Céline Arnathau Patrick Durand Nancy D Moukodoum Alain-Prince Okouga Barthélémy Ngoubangoye Boris Makanga Larson Boundenga Christophe Paupy François Renaud Franck Prugnolle Virginie Rougeron |
| author_sort | Aude Gilabert |
| collection | DOAJ |
| description | Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P. vivax-like, was discovered in African great apes and is hypothesized to have given rise to P. vivax in humans. To unravel the evolutionary history and adaptation of P. vivax to different host environments, we generated using long- and short-read sequence technologies 2 new P. vivax-like reference genomes and 9 additional P. vivax-like genotypes. Analyses show that the genomes of P. vivax and P. vivax-like are highly similar and colinear within the core regions. Phylogenetic analyses clearly show that P. vivax-like parasites form a genetically distinct clade from P. vivax. Concerning the relative divergence dating, we show that the evolution of P. vivax in humans did not occur at the same time as the other agents of human malaria, thus suggesting that the transfer of Plasmodium parasites to humans happened several times independently over the history of the Homo genus. We further identify several key genes that exhibit signatures of positive selection exclusively in the human P. vivax parasites. Two of these genes have been identified to also be under positive selection in the other main human malaria agent, P. falciparum, thus suggesting their key role in the evolution of the ability of these parasites to infect humans or their anthropophilic vectors. Finally, we demonstrate that some gene families important for red blood cell (RBC) invasion (a key step of the life cycle of these parasites) have undergone lineage-specific evolution in the human parasite (e.g., reticulocyte-binding proteins [RBPs]). |
| first_indexed | 2024-12-19T18:40:49Z |
| format | Article |
| id | doaj.art-3ff05e46b51f4265ba2c21cecd34f79e |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T18:40:49Z |
| publishDate | 2018-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-3ff05e46b51f4265ba2c21cecd34f79e2022-12-21T20:10:16ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-08-01168e200603510.1371/journal.pbio.2006035Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution.Aude GilabertThomas D OttoGavin G RutledgeBlaise FranzonBenjamin OllomoCéline ArnathauPatrick DurandNancy D MoukodoumAlain-Prince OkougaBarthélémy NgoubangoyeBoris MakangaLarson BoundengaChristophe PaupyFrançois RenaudFranck PrugnolleVirginie RougeronAlthough Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P. vivax-like, was discovered in African great apes and is hypothesized to have given rise to P. vivax in humans. To unravel the evolutionary history and adaptation of P. vivax to different host environments, we generated using long- and short-read sequence technologies 2 new P. vivax-like reference genomes and 9 additional P. vivax-like genotypes. Analyses show that the genomes of P. vivax and P. vivax-like are highly similar and colinear within the core regions. Phylogenetic analyses clearly show that P. vivax-like parasites form a genetically distinct clade from P. vivax. Concerning the relative divergence dating, we show that the evolution of P. vivax in humans did not occur at the same time as the other agents of human malaria, thus suggesting that the transfer of Plasmodium parasites to humans happened several times independently over the history of the Homo genus. We further identify several key genes that exhibit signatures of positive selection exclusively in the human P. vivax parasites. Two of these genes have been identified to also be under positive selection in the other main human malaria agent, P. falciparum, thus suggesting their key role in the evolution of the ability of these parasites to infect humans or their anthropophilic vectors. Finally, we demonstrate that some gene families important for red blood cell (RBC) invasion (a key step of the life cycle of these parasites) have undergone lineage-specific evolution in the human parasite (e.g., reticulocyte-binding proteins [RBPs]).https://doi.org/10.1371/journal.pbio.2006035 |
| spellingShingle | Aude Gilabert Thomas D Otto Gavin G Rutledge Blaise Franzon Benjamin Ollomo Céline Arnathau Patrick Durand Nancy D Moukodoum Alain-Prince Okouga Barthélémy Ngoubangoye Boris Makanga Larson Boundenga Christophe Paupy François Renaud Franck Prugnolle Virginie Rougeron Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. PLoS Biology |
| title | Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. |
| title_full | Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. |
| title_fullStr | Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. |
| title_full_unstemmed | Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. |
| title_short | Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution. |
| title_sort | plasmodium vivax like genome sequences shed new insights into plasmodium vivax biology and evolution |
| url | https://doi.org/10.1371/journal.pbio.2006035 |
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