Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles
Abstract Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause acute infections as well as chronic ones in humans. The expression of algD and PpyR genes involved in biofilm formation in clinical isolates of P. aeruginosa in the presence of Escherichia coli Nissle1917 outer mem...
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BMC
2023-09-01
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Series: | BMC Research Notes |
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Online Access: | https://doi.org/10.1186/s13104-023-06504-x |
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author | Maryam Alaei Fatemeh Aghakhani Sarvenaz Falsafi Hoora Mazaheri Ava Behrouzi |
author_facet | Maryam Alaei Fatemeh Aghakhani Sarvenaz Falsafi Hoora Mazaheri Ava Behrouzi |
author_sort | Maryam Alaei |
collection | DOAJ |
description | Abstract Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause acute infections as well as chronic ones in humans. The expression of algD and PpyR genes involved in biofilm formation in clinical isolates of P. aeruginosa in the presence of Escherichia coli Nissle1917 outer membranes vesicles (EcN OMVs) was evaluated. All isolates were tested for biofilm formation. qPCR and disk diffusion were used to identify the expression of algD and PpyR genes, and antimicrobial resistance, respectively. EcN OMVs caused a more significant loss of algD and PpyR expression, compared with the control group. EcN OMVs contain a variety of biomolecules that are capable of influencing the biofilm formation genes. EcN OMVs treatment reduced P. aeruginosa biofilm formation significantly, which emphasizes their positive role in inhibiting biofilm formation. As a result, EcN OMVs can be used as new therapeutic strategies for inhibiting P. aeruginosa biofilm formation. |
first_indexed | 2024-03-09T15:31:03Z |
format | Article |
id | doaj.art-3ff5df072e854e13b621d881f5fdc0fe |
institution | Directory Open Access Journal |
issn | 1756-0500 |
language | English |
last_indexed | 2024-03-09T15:31:03Z |
publishDate | 2023-09-01 |
publisher | BMC |
record_format | Article |
series | BMC Research Notes |
spelling | doaj.art-3ff5df072e854e13b621d881f5fdc0fe2023-11-26T12:14:25ZengBMCBMC Research Notes1756-05002023-09-011611710.1186/s13104-023-06504-xIntroduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesiclesMaryam Alaei0Fatemeh Aghakhani1Sarvenaz Falsafi2Hoora Mazaheri3Ava Behrouzi4Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad UniversityDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad UniversityDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad UniversityDepartment of Molecular Biology, Pasteur Institute of IranDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad UniversityAbstract Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause acute infections as well as chronic ones in humans. The expression of algD and PpyR genes involved in biofilm formation in clinical isolates of P. aeruginosa in the presence of Escherichia coli Nissle1917 outer membranes vesicles (EcN OMVs) was evaluated. All isolates were tested for biofilm formation. qPCR and disk diffusion were used to identify the expression of algD and PpyR genes, and antimicrobial resistance, respectively. EcN OMVs caused a more significant loss of algD and PpyR expression, compared with the control group. EcN OMVs contain a variety of biomolecules that are capable of influencing the biofilm formation genes. EcN OMVs treatment reduced P. aeruginosa biofilm formation significantly, which emphasizes their positive role in inhibiting biofilm formation. As a result, EcN OMVs can be used as new therapeutic strategies for inhibiting P. aeruginosa biofilm formation.https://doi.org/10.1186/s13104-023-06504-xalgDEcNPpyRPseudomonas aeruginosaOMVs |
spellingShingle | Maryam Alaei Fatemeh Aghakhani Sarvenaz Falsafi Hoora Mazaheri Ava Behrouzi Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles BMC Research Notes algD EcN PpyR Pseudomonas aeruginosa OMVs |
title | Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles |
title_full | Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles |
title_fullStr | Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles |
title_full_unstemmed | Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles |
title_short | Introduce a novel post-biotic against Pseudomonas aeruginosa biofilm formation using Escherchia coli Nissle1917 outer membrane vesicles |
title_sort | introduce a novel post biotic against pseudomonas aeruginosa biofilm formation using escherchia coli nissle1917 outer membrane vesicles |
topic | algD EcN PpyR Pseudomonas aeruginosa OMVs |
url | https://doi.org/10.1186/s13104-023-06504-x |
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