Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis
Background. Psoriatic erythroderma is rare and one of the most severe forms of psoriasis characterized by involvement of 8090% of body surface area. Aims. To compare clinical and demographic characteristics of patients with psoriasis, depending on presence of psoriatic erythroderma in medical his...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2023-01-01
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| Series: | Vestnik Dermatologii i Venerologii |
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| Online Access: | https://vestnikdv.ru/jour/article/viewFile/1328/pdf |
| _version_ | 1827832647434371072 |
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| author | Elena V. Bogdanova |
| author_facet | Elena V. Bogdanova |
| author_sort | Elena V. Bogdanova |
| collection | DOAJ |
| description | Background. Psoriatic erythroderma is rare and one of the most severe forms of psoriasis characterized by involvement of 8090% of body surface area.
Aims. To compare clinical and demographic characteristics of patients with psoriasis, depending on presence of psoriatic erythroderma in medical history; to assess the association between psoriatic arthritis and a history of psoriatic erythroderma.
Materials and methods. Patients aged 18 years and older with a duration of psoriasis of 10 years, from the psoriasis patients registry were included.
Comparison of continuous quantitative variables was performed using t-test or MannWhitney U-test. The 2 test or Fisher's exact test was used to compare qualitative binary variables.
The odds ratio of psoriatic arthritis in patients with and without a history of psoriatic erythroderma was calculated, unadjusted and adjusted for other independent variables.
Results. The number of patients included in the analysis was 1,870. A history of psoriatic erythroderma (PE) had 227 (12.1%) of them. There were no significant differences in patient age at inclusion to the registry (47.1 13.1 years vs. 47.7 13.3 years), and prevalence of PE among men and women (12.6% vs. 11. 4%).
Higher prevalence of arterial hypertension (47.9% vs 32.7%), angina pectoris (6.4% vs. 1.9%), myocardial infarction (3.2% vs. 1.0%), biliary dyskynesia (14.3% vs. 3.9%), fatty liver (12.2% vs. 7.7%), cholelithiasis (8.6% vs. 3.6%), and toxic liver disease (2.2% vs. 0.5%) among patients with vs without history of PE was found.
Psoriatic arthritis was diagnosed in 67.0% patients with a history of psoriatic erythroderma. The odds of having psoriatic arthritis in patients with a history of psoriatic erythroderma were 4 times higher than in patients without erythroderma: 4.043 [2.9755.493]. When adjusted for sex, age, duration of psoriasis, and body mass index, the odds ratio and statistical significance were maintained: 4.064 [2.9395.619].
Conclusions. Compared to patients without PE those with a history of psoriatic erythroderma have a greater comorbidity burden: a higher prevalence of cardiovascular diseases, diseases of the liver and biliary tract. A significant association between psoriatic arthritis and a history of PE was established. |
| first_indexed | 2024-03-12T05:16:30Z |
| format | Article |
| id | doaj.art-3ff9a10453084998bc2d072389b96320 |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T05:16:30Z |
| publishDate | 2023-01-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-3ff9a10453084998bc2d072389b963202023-09-03T08:05:31ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942023-01-01986738010.25208/vdv13281189Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritisElena V. Bogdanova0https://orcid.org/0000-0002-0662-2682State Research Center of Dermatovenereology and CosmetologyBackground. Psoriatic erythroderma is rare and one of the most severe forms of psoriasis characterized by involvement of 8090% of body surface area. Aims. To compare clinical and demographic characteristics of patients with psoriasis, depending on presence of psoriatic erythroderma in medical history; to assess the association between psoriatic arthritis and a history of psoriatic erythroderma. Materials and methods. Patients aged 18 years and older with a duration of psoriasis of 10 years, from the psoriasis patients registry were included. Comparison of continuous quantitative variables was performed using t-test or MannWhitney U-test. The 2 test or Fisher's exact test was used to compare qualitative binary variables. The odds ratio of psoriatic arthritis in patients with and without a history of psoriatic erythroderma was calculated, unadjusted and adjusted for other independent variables. Results. The number of patients included in the analysis was 1,870. A history of psoriatic erythroderma (PE) had 227 (12.1%) of them. There were no significant differences in patient age at inclusion to the registry (47.1 13.1 years vs. 47.7 13.3 years), and prevalence of PE among men and women (12.6% vs. 11. 4%). Higher prevalence of arterial hypertension (47.9% vs 32.7%), angina pectoris (6.4% vs. 1.9%), myocardial infarction (3.2% vs. 1.0%), biliary dyskynesia (14.3% vs. 3.9%), fatty liver (12.2% vs. 7.7%), cholelithiasis (8.6% vs. 3.6%), and toxic liver disease (2.2% vs. 0.5%) among patients with vs without history of PE was found. Psoriatic arthritis was diagnosed in 67.0% patients with a history of psoriatic erythroderma. The odds of having psoriatic arthritis in patients with a history of psoriatic erythroderma were 4 times higher than in patients without erythroderma: 4.043 [2.9755.493]. When adjusted for sex, age, duration of psoriasis, and body mass index, the odds ratio and statistical significance were maintained: 4.064 [2.9395.619]. Conclusions. Compared to patients without PE those with a history of psoriatic erythroderma have a greater comorbidity burden: a higher prevalence of cardiovascular diseases, diseases of the liver and biliary tract. A significant association between psoriatic arthritis and a history of PE was established.https://vestnikdv.ru/jour/article/viewFile/1328/pdfpsoriasispsoriatic erythrodermapsoriatic arthritis |
| spellingShingle | Elena V. Bogdanova Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis Vestnik Dermatologii i Venerologii psoriasis psoriatic erythroderma psoriatic arthritis |
| title | Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis |
| title_full | Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis |
| title_fullStr | Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis |
| title_full_unstemmed | Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis |
| title_short | Psoriatic erythroderma: comparative patient profile and association with psoriatic arthritis |
| title_sort | psoriatic erythroderma comparative patient profile and association with psoriatic arthritis |
| topic | psoriasis psoriatic erythroderma psoriatic arthritis |
| url | https://vestnikdv.ru/jour/article/viewFile/1328/pdf |
| work_keys_str_mv | AT elenavbogdanova psoriaticerythrodermacomparativepatientprofileandassociationwithpsoriaticarthritis |